Lack of association between genetic variations in the visfatin gene promoter region and ischemic stroke in the northern Chinese Han population
- VernacularTitle:Visfatin基因启动子区域的遗传变异与中国北方汉族人群缺血性卒中发病风险研究
- Author:
Ruixia ZHU
1
;
Qianwen WANG
1
;
Xu LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Ischemic Stroke; Genetic Polymorphism; Visfatin
- From: Journal of Apoplexy and Nervous Diseases 2020;37(7):633-637
- CountryChina
- Language:Chinese
- Abstract: Objective Visfatin, a newly identified pro-inflammatory adipokine, has been related to atherosclerosis,therefore we explore the association between the visfatin rs61330082 and ischemic stroke risk. The -1535 polymorphism (rs61330082) located in the visfatin gene promoter is reportedly associated with inflammatory related atherosclerosis. Method A total of 368 ischemic stroke patients and 381 healthy controls were enrolled for the study. The rs61330082 polymorphism was genotyped by the polymerase chain reaction-ligase detection reaction (PCR-LDR) sequencing method. Results No significant differences in genotypic and allelic frequencies between ischemic stroke patients and healthy controls were observed even when the OR was adjusted for the clinical variables. We also did not find any significant association from sex subtypes. Conclusion Visfatin rs61330082 polymorphism is not associated with ischemic stroke risk in the northern Chinese Han population.
- Full text:202408012205061532Lack of association between genetic variations in the visfatin gene promoter region and ischemic stroke in the northern Chinese Han population.pdf
