Effects of systolic blood pressure and diastolic blood pressure on White matter lesions：a meta-analysis
- VernacularTitle: 收缩压与舒张压水平对脑白质病变的影响：Meta分析
- Author:
Dong ZHANG
1
;
Mingli HE
1
;
Jian GE
1
Author Information
- Publication Type:Journal Article
- Keywords: Blood pressure; White matter lesions; Hypertension; Meta-analysis
- From: Journal of Apoplexy and Nervous Diseases 2020;37(7):600-606
- CountryChina
- Language:Chinese
- Abstract: Objective To systematically evaluate the effect of systolic and diastolic blood pressure on the progression of White matter lesions. Methods The title term “white matter” “Leukoencephalopathy” “leukoaraiosis” “blood pressure” “hypertension” in PubMed and Cochrane Library were searched for 174 AND 101 articles respectively from 1981 to August 2019.Then two researchers independently screened AND evaluated the included literatures，AND meta-analysis was performed using RevMan 5.3 software. Results Finally，a total of 11 closely related studys were included for research. The results of meta-analysis showed that the increase of systolic blood pressure and diastolic blood pressure could promote the progression of white matter lesions（Respectively OR=2.90，95%CI 2.86～2.95；OR=3.13，95%CI 3.03～3.23），especially in diastolic blood pressure. Conclusion The increase of systolic blood pressure and diastolic blood pressure can promote the progress of white matter lesions，but it is more closely related to diastolic blood pressure. Therefore，more researchers are expected to pay attention to the change of diastolic blood pressure，and more importantly，to identify the range of blood pressure and control strategies that control diastolic blood pressure is beneficial to delay the progress of white matter lesions，especially for patients under 70 years old.
- Full text:2024080121531543472收缩压与舒张压水平对脑白质病变的影响_Meta分析.pdf
