Study on the relationship between MMP-2，MMP-14 and the vulnerability of carotid plaque based on immunohistochemistry
- VernacularTitle: 基于免疫组化法研究MMP-2、MMP-14与颈动脉粥样斑块易损性的相关性
- Author:
Zhouying GUO
1
;
Shuqin ZHANG
1
;
Haocheng QING
1
Author Information
- Publication Type:Journal Article
- Keywords: Carotidplaque / Vascular ultrasonography; Matrix metalloproteinases; Vulnerability; Relevance
- From: Journal of Apoplexy and Nervous Diseases 2020;37(7):580-584
- CountryChina
- Language:Chinese
- Abstract: Objective We investigated the correlation of MMP-2，MMP-14 with the vulnerability of carotid plaque. Our study was to explore the related factors which influence the stability of the plaques. Methods Carotid plaques were collected from patients undergoing CEA in the Department of Neurosurgery of the First people’s Hospital of Lianyungang. 55 patients were recruited between January 2018 and June 2019.All of the plaques were divided into 23 stable carotid plaques and 32 vulnerable carotid plaques by imaging and histological analysis. Immunohistochemistry was used toloca lize the expression level of MMP-2 and MMP-14 in stable and vulnerable plaques. Results Density analysis revealed that the immunohistochemical staining of MMP-2 and MMP-14 were more intense among samples from vulnerable group than those from stable group. MMP-2 and MMP-14 staining was positive in ulcer plaque and the atheromatous lesions. Conclusion The expression of MMP-2 and MMP-14 were associated with plaque vulnerability of human carotid plaques，which is an important factor affecting the stability of plaques.
- Full text:2024080121405819549基于免疫组化法研究MMP-2、_MMP-14与颈动脉粥样斑块易损性的相关性.pdf
