Correlation between NT-proBNP and causes of acute cerebral infarction，severity of neurological deficits，prognosis
- VernacularTitle:N末端-前B型脑钠肽与急性脑梗死病因、神经功能缺损严重度及预后的相关性分析
- Author:
Xia SHA
1
;
Jianhua ZHUANG
1
;
Bin ZHU
1
Author Information
- Publication Type:Journal Article
- Keywords: NT-proBNP ； Acute cerebral infarction ； Neurological deficit ； Etiology ； Severity ；Prognosis
- From: Journal of Apoplexy and Nervous Diseases 2020;37(9):817-822
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the correlation between N-terminal pro-brain natriuretic peptide （NT-proBNP） and causes of acute cerebral infarction （ACI），severity of neurological deficits，prognosis，so as to provide reference for clinical intervention of ACI. Methods Eighty patients with ACI who were admitted to the hospital from January 2017 to April 2019 were selected as ACI group. Forty healthy volunteers who underwent physical examination in the hospital during the same period were enrolled as control group. Blood samples were collected from two groups （within 24 h～48 h after onset in patients with ACI） to detect the NT-proBNP level. The etiological types in the trial of Org10172 in acute stroke treatment （TOAST） were recorded. National Institutes of Health Stroke Scale （NIHSS） was applied to evaluate severity of neurological deficits at admission. The modified Rinkin Scale （MRS） was applied to evaluate prognosis after 3 months of admission. Blood NT-proBNP levels in patients with different general data and cardiac indicators were compared. The multiple linear regression analysis was applied to analyze correlation between serum NT-proBNP level and TOAST etiological type，severity of neurological deficits，prognosis in ACI patients. Results ①The serum NT-proBNP in ACI patients was significantly higher than that in control group （P<0.001）. ②The serum NT-proBNP in ACI patients with type cardiac embolism （CE） as TOAST etiology typing，NIHSS score not lower than 7 points，mRS not lower than 3 points，with atrial fibrillation and thickened interventricular septum thickness （IST） were significantly higher than that in patients with non-CE type，NIHSS score within 0-6 points，mRS lower than 3 points，without atrial fibrillation and with normal IST （P<0.05）. ③The multiple linear regression analysis showed that type CE as TOAST etiology typing，severity of neurological deficits （NIHSS score） and mRS after 3 months of admission were closely related to serum NT-proBNP （P<0.05）. And Pearson correlation coefficients （r） were 0.822，0.545 and 0.452，respectively. Conclusion After 24 h～48 h of onset in ACI patients，there is good correlation between serum NT-proBNP and etiology typing of TOAST，severity of neurological deficits，prognosis，which deserves clinical attention.
- Full text:2024073122130462662N末端-前B型脑钠肽与急性脑梗死病因、_神经功能缺损严重度及预后的相关性分析.pdf
