Exploring the clinical effect of dl-3-N-butylphthalide（NBP）injection combined with antiplatelet drug therapy and the influence on stroke recurrence of minor stroke patients
- VernacularTitle: 丁苯酞注射液联合抗血小板药物治疗对轻型卒中的临床疗效及卒中复发风险影响的探究
- Author:
Wenqi TIAN
1
;
Jianjian WANG
1
;
Lihua WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Minor stroke ； Dl-3-N-butylphthalide（NBP） ； Stroke recurrence ；Neurological function
- From: Journal of Apoplexy and Nervous Diseases 2020;37(9):787-792
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the clinical effect of dl-3-N-butylphthalide（NBP）injection combined with antiplatelet drug therapy and the influence on stroke recurrence of minor stroke patients. Methods A retrospective analysis was performed on 95 patients with minor stroke that admitted to the stoke center of the second affiliated hospital of Harbin Medical University from January to July 2019.It included 45 patients in the combined treatment group （NBP plus antiplatelet treatment group） and 50 patients in the control group （antiplatelet treatment group）. The mRS score，NIHSS score and BI of the two groups were analyzed at 14 days，1 month，3 months and 6 months after treatment. The stroke recurrence events at 1 month，3 months，and 6 months after treatment in both groups will be recorded too. We used multivariate analysis to analyze the factors that might influence stroke recurrence in minor stroke patients. Results ①There was no significant difference in baseline information between the two groups（P>0.05），which was comparable. ②At 14 days，1 month，3 months and 6 months after treatment，the mRS scores and NIHSS scores of the patients in the two groups were significantly lower than that at admission，while the Barthel index were significantly higher than that at admission （P<0.01）. ③In the combined treatment group at 1 month，3 months and 6 months after treatment，the mRS scores were significantly lower than those in the control group （P=0.033，0.031，0.013）. ④The number of the combined treatment group patients with stroke recurrence at 3 months and 6 months after treatment was significantly lower than that in the control group（P=0.033，0.039）. ⑤The results of multivariate analysis showed that using NBP was an independent protective factor in stroke recurrence at 3 months （OR=0.060，95%CI 0.005～0.778，P=0.031） and 6 months （OR=0.163，95%CI 0.028～0.968，P=0.028） for minor stroke. Conclusion NBP combined with antiplatelet drugs can significantly improve the neurological function and reduce the stroke recurrence of minor stroke patients.
- Full text:2024073121522276854丁苯酞注射液联合抗血小板药物治疗对轻型卒中的临床疗效及卒中复发风险影响的探究.pdf
