The changes of P-gp and TGFβ1 in cerebrospinal fluid of drug-resistant epilepsy
- VernacularTitle:耐药性癫痫脑脊液P-糖蛋白、转化生长因子β1水平变化的临床意义研究
- Author:
Liniu CHENG
1
;
Shufeng BAI
1
;
Junqiang YAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Drug-resistant epilepsy; P-glycoprotein; Transforming growth factor β1; Diagnosis
- From: Journal of Apoplexy and Nervous Diseases 2020;37(10):908-910
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the clinical significance of P-gp and TGFβ1 in cerebrospinal fluid (CSF) of drug-resistant epilepsy.Methods Thirty responsive epilepsy patients were selected as sensitive group,30 cases of drug-resistant epilepsy were drug-resistant group,20 healthy persons were selected as control group.The levels of P-gp and TGFβ1 in CSF of all subjects were measured by ELISA,and the results were compared between groups.The levels of P-gp and TGFβ1 in patients with different seizure types in drug-resistant group were compared at the same time.Results P-gp and TGFβ1 in CSF of drug-resistant group were (21.5±3.1) ng/ml and (217.3±49.6) pg/ml respectively,which were significantly higher than that of sensitive group and control group (P<0.05).The levels of P-gp and TGFβ1 in CSF were no significantly different between sensitive group and control group (P>0.05).The levels of P-gp and TGFβ1 in CSF of drug-resistant epilepsy patients with different seizure types had no significant difference (P>0.05).Conclusion The levels of P-gp and TGFβ1 in CCSF can be used as an important detection marker for drug-resistant epilepsy of different seizure types.
- Full text:2024073119534539789The changes of P-gp and TGFβ1 in cerebrospinal fluid of drug-resistant epilepsy.pdf
