Application value of diffusion tensor imaging in the diagnosis and quantitative analysis of parkinson’s disease
10.19845/j.cnki.zfysjjbzz.2020.0480
- VernacularTitle:磁共振弥散张量成像在帕金森病诊断与定量分析中的应用价值
- Author:
Longjun GUO
1
;
Changhua LIANG
1
Author Information
1. Department of Radiology,The First Affiliated Hospital of Xinxiang Medical University,Henan 453100,China
- Publication Type:Journal Article
- Keywords:
Parkinson’s disease;
Diffusion tensor imaging;
Apparent diffusion coefficient;
Fractional anisotropy;
Quantitative diagnosis
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(10):900-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of diffusion tensor imaging (DTI) in the diagnosis and quantitative analysis of parkinson's disease (PD).Methods Forty five patients with PD in our hospital from December 2017 to October 2019 were selected as the observation group,and 39 healthy people were selected as the control group.Two groups were examined by DTI,and the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) value were measured and analyzed statistically.Results The FA value of thalamus and substantia nigra in the observation group were lower than those of the control group (P<0.05).There was no significant difference in ADC value of thalamus,substantia nigra,pons,superior cerebellar peduncle and middle peduncle between the two groups (P>0.05).The results of ROC curve showed that:the AUC of FA value in thalamus and substantia nigra was 0.704 and 0.798,respectively (P<0.05).The FA value of substantia nigra in PD patients with mid-Hoehn-Yahr stage was lower than that of early stage,and the ADC value of thalamus was higher than that of early stage (P<0.05). Pearson correlation analysis showed that:the FA value of substantia nigra was negatively correlated with Hoehn-Yahr stage of PD patients (r=-0.457,P=0.002);the ADC value of thalamus was positively correlated with Hoehn-Yahr stage of PD patients (r=0.405,P=0.006).Conclusion DTI has a quantitative diagnostic value for PD,and FA value of substantia nigra and ADC value of thalamus were correlated with PD condition.
- Full text:2024073118373586033磁共振弥散张量成像在帕金森病诊断与定量分析中的应用价值.pdf
