The relationship between the level of serum lipoprotein associated phospholipase A2 and the condition and prognosis of patients with acute ischemic stroke
10.19845/j.cnki.zfysjjbzz.2020.0475
- VernacularTitle: 血清脂蛋白相关磷脂酶A2水平与急性缺血性脑卒中患者病情及预后的关系
- Author:
Limei CAO
1
;
Bin JIANG
1
;
Yuangao LIAO
1
Author Information
1. Department of Neurology,First People Hospital of Chenzhou City,Chenzhou 423000,China
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Lipoprotein associated phospholipase A2;
Condition;
Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(10):877-880
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the level of Lp-PLA2 and the condition as well as prognosis of patients with acute ischemic stroke.Methods The general data of 120 patients with acute ischemic stroke and 92 healthy persons were collected.The serum Lp-PLA2 levels were detected by ELISA.NIHSS scale was used to assess the severity of the disease at admission.mRS was used to evaluate the prognosis 3 months after discharge.The correlation between serum Lp-PLA2 level and the severity of the disease was analyzed.The risk factors of prognosis were analyzed.Results The proportion of hypertension and the level of serum Lp-PLA2 in patients with acute ischemic stroke were significantly higher than those in control group (P<0.05).Among 120 patients with acute ischemic stroke,47 cases were mild,38 cases were moderate,and 35 cases were severe.There was significant difference in serum Lp-PLA2 level among the three groups (P<0.05).Pearson correlation analysis showed that serum Lp-PLA2 levels were positively correlated with NIHSS score (P<0.05).Among 120 patients with acute ischemic stroke,81 cases had good prognosis and 39 cases had poor prognosis.The age of patients in poor prognosis group was significantly longer than that in good prognosis group (P<0.05),the time from onset to admission was significantly longer than that in good prognosis group (P<0.05),and serum Lp-PLA2 levels were significantly higher than that in good prognosis group (P<0.05).Multivariate logistic regression analysis showed that age and Lp-PLA2 were risk factors for prognosis of patients with acute ischemic stroke(P<0.05).Conclusion The higher the level of Lp-PLA2,the more serious the disease is.Lp-PLA2 is a risk factor of prognosis in patients with acute ischemic stroke.
- Full text:2024073118195205268血清脂蛋白相关磷脂酶A2水平与急性缺血性脑卒中患者病情及预后的关系.pdf
