Bioinformatics and drugs analysis of focal cortical dysplasia
10.19845/j.cnki.zfysjjbzz.2020.0474
- VernacularTitle:局灶性皮质发育不良基因表达的生物信息学及药物分析
- Author:
Yiran ZHAO
1
;
Yinchao LI
1
;
Shuda CHEN
1
Author Information
1. Department of Neurology,The Seven Affiliated Hospital,Sun Yat-Sen University,Shenzhen 518107,China
- Publication Type:Journal Article
- Keywords:
Bioinformatics;
Focal cortical dysplasia;
Gene chip;
Drugs
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(10):872-876
- CountryChina
- Language:Chinese
-
Abstract:
Objective The molecular mechanisms of the pathogenesis underlying focal cortical dysplasias (FCD) remain unclear.The aims of this study is to find out the potential gene markers and drugs for FCD.Methods We analyzed the GSE62019 datasets,including tissue from five FCD patients and three controls,to identify differentially expressed genes.Afterwards,the gene ontology and signaling pathway enrichment analyses of these DEGs were performed using online software.Protein and protein interaction networks were constructed and the significant gene modules were chosen for further gene-drug interaction analysis.Furthermore,the existing drugs target to these module genes were screen to explore the therapeutic effect for FCD.Results We identified 777 DEGs,including 364 down-regulated genes and 413 up-regulated genes,respectively.One core module of DEGs was selected.Moreover,the significant module genes in PPI networks were C3,SAA1,ANXA1,CXCL2 and CCL25,and several existing drugs have targeted to those genes.Conclusion We identified 5 potential genes and several existing drugs for FCD,which might be used as targets for the study of FCD.
- Full text:2024073118150904113Bioinformatics and drugs analysis of focal cortical dysplasia.pdf
