The Gender and Clinical Symptoms Difference in Depression of Parkinson’s Disease
- VernacularTitle:帕金森病伴发抑郁的临床特征及性别差异
- Author:
Yamin WANG
1
;
Erfeng LI
1
;
Li JIANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson’s disease; Depression of parkinson’s disease; Non-motor symptoms; Gender differences; Motor symptoms
- From: Journal of Apoplexy and Nervous Diseases 2020;37(11):989-993
- CountryChina
- Language:Chinese
- Abstract: Objective We aimed to analyze the gender differences by evaluating the motor and non-motor symptoms among the patients with parkinson’s disease and the patients with depression of parkinson’s disease，and to explore the possible pathogenesis further and make sex-specific therapeutic strategies. Methods Two hundred patients with parkinson’s disease from both the outpatients department and the ward were included in this analysis. There were 56 patients whose HAMD scores exceeded 19，which were divided into the depession of parkinson’s disease （dPD） group。There are 144 patients whose HAMD scores under 20，which were divided into the non-depession of parkinson’s disease （ndPD） group. The scores from all the scales were analyzed using statistical software. Results ①The depression incidence of females was significantly higher than that of males in PD patients （P<0.05）. ②Rigidity score and Bradykinesia score in males were significantly higher than that in females in dPD patients （P<0.05）. Tremor score in males was significantly lower than that in females in dPD patients （P<0.05）. ③A significantly higher score in mood/apathy and feel problem/hallucination domains were observed in female PD patients （P<0.05）. ④The HAMA score，HAMD score，NMSQ total score of dPD patients were all significantly higher than that of ndPD patients （P<0.05）. The PDSS score of dPD patients was significantly lower than that of ndPD patients （P<0.05）. The tremor score，rigidity score，postural instability score，bradykinesia score，UPDRS-III score of dPD patients were all significantly higher than that of ndPD patients （P<0.05）. ⑤The HAMD scores correlated with levodopa equivalent doses （Led） （r=-0.31，P=0.01），H-Y stage （r=0.23，P=0.03），PDSS （r=0.36，P=0.01） and rigidity （r=0.27，P=0.04） scores. Conclusion ①There are gender differences bewteen males and females in motor disorders in depression of parkinson’s disease. ②The motor disorders and non-motor disorders were more severe in depression of parkinson’s disease than in non-depression of parkinson’s disease. ③The HAMD score in depression of parkinson’s disease correlated with levodopa equivalent doses，the motor disorders and the non-motor disorders. ④The spectrum of motor and non-motor symptoms showed different gender distribution in PD and dPD patients. Gender-specific therapeutic agents hold particula attention for developing treatments with optimal efficaty in men and women in the future.
- Full text:202407311523383286帕金森病伴发抑郁的临床特征及性别差异.pdf
