Incidence of Depression among Parkinson’s Disease in China：A Meta-Analysis
- VernacularTitle:中国帕金森病患者抑郁情绪发生率的Meta分析
- Author:
Shuqi HUANG
1
;
Siqing LI
1
;
Shuangyan TU
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson’s Disease; Depression; Incidence; Meta-analysis
- From: Journal of Apoplexy and Nervous Diseases 2020;37(11):984-988
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the rate of depression among Chinese Parkinson’s disease patients by Meta-analysis. Methods CNKI，VIP，Wanfang，PubMed，Web of Science and Embase databases were searched systematically. The studies focus on depression of Parkinson’s disease patients in China from the year of establishment to 2019 were collected. Two researchers independently screened literature，extracted data and applied the standard of Agency for Healthcare Research and Quality to evaluate the quality of literatures. According to the results of heterogeneity test，the data were analyzed by Stata 12.0 software using random effect model. Results A total of 7842 PD patients，4394 males and 3088 females，were included in 37 studies. The combined value of depression detection rate was 43.0% ［95%CI （0.370，0.490）］. Subgroup analysis showed that the incidence of depression in the study with sample size<150 was 47.7% ［95%CI （0.413，0.542）］，and the incidence of depression in the study with sample size≥ 150 was 34.3% ［95%CI （0.254，0.432）］，respectively. The prevalence rates of depression with assessment tools were different，Hamilton Depression Rating for Depression 43.0%［95%CI（0.359，0.501）］，Center for Epidemiologic Studies Depression Scale 38.1% ［95% CI （0.301，0.461）］，Self-Rating Depression Scale 41.0% ［95%CI （0.163，0.657）］，Beck Depression Inventory 46.0% ［95%CI （0.353，0.567）］. The incidence of depression in female PD patients was 43.0% ［95%CI（0.340，0.519）］，43.2% ［95%CI （0.330，0.533）］ in male. The incidence of depression was 43.2% ［（95%CI （0.330，0.533）］，among patients disease duration ≤ 5 years，44.4% ［（95%CI （0.362，0.501）］ in patients with PD whose disease duration more than 5 years. The incidence of depression was 40.2%［95%CI（0.226，0.538）］in PD patients whose onset age ≥60 years，45.3% ［95%CI（0.335，0.570）］in PD patients whose onset age <60 years. The incidence of depression was 45.4%［95%CI（0.441，0.497）］in patients with UPDRSIII score > 25，39.1%［95%CI（0.261，0.521）］ in those with score ≤ 25.42.1%［95%CI（0.303，0.538）］PD patients with mild depression，22.7%［95%CI（0.160，0.293）］with moderate depression and 7.4%［95%CI（0.049，0.100）］ with severe depression. Conclusion The incidence of depression is high in PD patients. The emotion of PD patients in every stage need evaluate，diagnose and cure earlier.
- Full text:2024073115213720541中国帕金森病患者抑郁情绪发生率的Meta分析.pdf
