The clinical features of 17 patients with the myelin oligodendrocyte glycoprotien antibody-associated disease
10.19845/j.cnki.zfysjjbzz.2020.0529
- VernacularTitle:17例髓鞘少突胶质细胞糖蛋白抗体相关疾病患者的临床分析
- Author:
Shaodan ZHOU
1
;
Ju FU
1
;
Xiuqun BU
1
Author Information
1. Department of Neurology,Minzu Hospital of Guangxi Zhuang Autonomous Region,Affiliated Minzu Hospital of Guangxi Medical University,Nanning 530001,China
- Publication Type:Journal Article
- Keywords:
Myelin oligodendrocyte glycoprotien;
Optic neuritis;
Neuromyelitis optica spectrum disorder;
Multiple sclerosis
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(12):1105-1108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of the myelin oligodendrocyte glycoprotien antibody-associated disease(MOGAD).Methods The clinical data of 17 MOGAD patients who were hospitalized in The First Affiliated Hospital of Sun Yat-sen University from January 2017 to June 2019 were retrospectively analyzed.Then we summarized the clinical and imagine features of the MOGAD.Results Seventeen patients,including 11 males and 6 females,were recruited in this study,and the average age of onset was (27.76±12.22)years old.Ten patients presented as ON,9 cases manifested as myelitis,10 cases presented as the symptoms of brain damage,and 1 case as the ADEM.The MOG antibody in serum of 17 patients were positive,and the MOG antibody titers were from 1:10 to 1:320.Among them,the MOG antibody in cerebrospinal fluid of 7 patients were positive,and the antibody titers were from 1:1 to 1:32.Other autoimmune antibodies were positive in a small group of these patients.Magnetic resonance imaging(MRI) scan are abnormal in all the patients at onset.The majority lesions appear as poorly demarcated hyperintensities on T2-weighted and T2FLAIR images,some of them showed edge enhancement.All patients were treated with intravenous methylprednisolone,and 13 patients were treated with IVIG.The symptoms of 16 cases were improved within a month,and another case improved after the plasma exchange.And 6 cases recurred within a year.Conclusion The clinical features of the MOGAD were various,mainly including ON,myelitis,encephalitis,meningoencephalitis i.e.Early immunotherapy can result in having a complete or almost complete recovery.However,some patients had the risk of relapse.
- Full text:2024073115011018330The clinical features of 17 patients with the myelin oligodendrocyte glycoprotien antibody-associated disease.pdf
