Clinical characteristics of 14 patients with autoimmune glial fibrillary acidic protein astrocytosis with central nervous system inflammation as the main manifestation
10.19845/j.cnki.zfysjjbzz.2020.0528
- VernacularTitle:以中枢系统炎症为主要表现的14例自身免疫性胶质纤维酸性蛋白星形细胞病患者的临床特征分析
- Author:
Jinlong YE
1
;
Weijing ZHANG
1
;
Youming LONG
1
Author Information
1. Guang Dong 999 Brain Hospital,Guangzhou 510510,China
- Publication Type:Journal Article
- Keywords:
Autoimmune disease;
Glialfibrillaryacid protein;
Meningitis;
Encephalomyelitis;
Myelitis
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(12):1101-1104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of patients with autoimmune glial fibrillary acidic protein(GFAP) astrocytosis with central nervous system inflammation as the main manifestation.Methods Twenty-one patients with autoimmune GFAP astrocytosis with positive cerebrospinal fluid GFAP antibody were collected from January 2017 to April 2020.The clinical data of 14 patients with cerebrospinal fluid GFAP antibody positive were retrospectively analyzed.Results Among the 14 patients,4 were female and 10 were male.The age of onset was(42±16) years old.The main clinical manifestations of the patients were headache(13/14),fever(13/14),disturbance of consciousness(11/14),mental symptoms(10/14),epilepsy(4/10),defecation disorder(8/14),hypoxemia(6/14),limb paralysis(2/14),etc.MRI showed abnormal enhancement of intracranial meninges in 13 cases(13/14) and spinal cord involvement in 5 cases(5/14).Conclusion There are more males than females with autoimmune GFAP astrocytosis with cerebrospinal meningitis and other central system inflammation.MRI manifestations are complex.Intracranial and spinal cord can be involved at the same time.Intracranial lesions mainly involve meninges,which can be combined with cerebral cortex damage.In myelopathy,both the spinal cord and the spinal cord are involved,and the spinal cord membrane is mainly involved.
- Full text:2024073114585182146Clinical characteristics of 14 patients with autoimmune glial fibrillary acidic protein astrocytosis with central nervous system inflammation as the main manifestation.pdf
