Analysis of incidence rate and risk factors for spontaneous hemorrhagic transformation in acute cerebral infarction patients
10.19845/j.cnki.zfysjjbzz.2020.0522
- VernacularTitle:急性脑梗死自发性出血转化发生率及危险因素分析
- Author:
Li ZHANG
1
;
Lihua SHAO
1
;
Jun XIA
1
Author Information
1. Department of Neurology,the First People Hospital of Changde City,Changde 415000,China
- Publication Type:Journal Article
- Keywords:
Acute cerebral infarction;
Spontaneous hemorrhagic transformation;
Risk factors
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(12):1075-1079
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the incidence rate and risk factors for spontaneous hemorrhagic transformation(HT) in acute cerebral infarction(ACI) patients.Methods We retrospectively reviewed the clinical records of 216 ACI patients undergoing drug conservative treatment in the First People's Hospital of Changde City from January 2018 to January 2019.According to the occurrence of the spontaneous HT in each person within 14 days after onset,all patients were divided into two groups:the HT group and none-HT group,the clinical data between each group were be compared,univariate and multivariate logistic regression were used to analyze the relevant risk factors,the association between the risk factor and the spontaneous HT were further assessed by linear regression models and smooth curve fitting in addition to threshold effect analysis.Results Among 216 patients with ACI,27 cases(12.5%) had spontaneous HT during hospitalization.Multivariate logistic regression analysis showed that the etiological types in the trial of Org10172 in acute stroke treatment(TOAST)of cardiac embolism(CE)(OR=11.05,95%CI 1.97~61.98;P=0.0063),high National Institutes of Health Stroke Scale (NIHSS) score on the first day of admission (OR=1.6,95%CI 1.3~2.0;P<0.001),and excessive peripheral leukocyte counts excluding inflammatory response at admission (OR=1.41,95%CI 1.01~1.95;P=0.0408) were independent risk factors for the spontaneous HT after ACI.Smooth curve fitting analysis showed that the peripheral white blood cell count and the occurrence of the spontaneous HT were positively correlated.Conclusion TOAST classification of CE,high NIHSS score on the first day of admission and excessive peripheral leukocyte counts excluding inflammatory response at admission were independent risk factors of spontaneous HT after ACI.The excessive peripheral leukocyte counts after acute cerebral infarction,independently of the occurrence of infections,could be a potential predictor of the spontaneous HT after ACI.
- Full text:2024073114454175855Analysis of incidence rate and risk factors for spontaneous hemorrhagic transformation in acute cerebral infarction patients.pdf
