Role of anterior forbrain thalamic loop in hypothermia induced brain protection during global cerebral ischemia
10.19845/j.cnki.zfysjjbzz.2020.0520
- VernacularTitle:前前脑-丘脑环路在全脑缺血期间低温诱导的脑保护中的作用
- Author:
Xiaohua WANG
1
;
Bingbing NIE
1
;
Yanhong LI
1
Author Information
1. Department of Anesthesiology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China
- Publication Type:Journal Article
- Keywords:
Cardiac arrest;
Global cerebral ischemia;
Hypothermia;
Anterior forebrain mesocircuit
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(12):1065-1069
- CountryChina
- Language:Chinese
-
Abstract:
Objective Cardiac arrest is a major cause of death worldwide.Hypothermia is an important protective method against global cerebral ischemia (GI) following cardiac arrest.However,the mechanisms of hypothermia underlying the changes in different regions and nodes of the brain have not been fully elucidated.Methods In this study,We investigated the metabolism of brain and its nodes in rat hypothermia GI and normothermia GI models using positron emission tomography (PET) and magnetic resonance imaging (MRI).Voxel-based analysis was used to assess the metabolic nodes.To identify the cerebral circuit of potential hypothermia protection,a white matter network of hypothermia GI and normothermia GI was constructed using fractional anisotropy from diffusion tensor imaging (DTI) and the nuclei on the pathway were also identified.Results The PET voxel-based analysis demonstrated that there was significant reduce hypometabolic region of the brain in the hypothermia GI group compared with that in the normothermia GI group.Hypothermia selectively preserved the mesocircuit including the thalamus,prefrontal cortex,and the connections between them,including those between the corpus callosum and internal capsule.Conclusion In rats that underwent hypothermia,the preserved functional integrity of the anterior forebrain mesocircuit.We provide evidence that the anterior forebrain mesocircuit is relatively preserved in hypothermia and has an important role in cerebral protection.
- Full text:2024073114403590729Role of anterior forbrain thalamic loop in hypothermia induced brain protection during global cerebral ischemia.pdf
