Mechanism of Chinese Medicine Against Diabetic Gastroparesis： A Review
10.13422/j.cnki.syfjx.20240221
- VernacularTitle:中药防治糖尿病胃轻瘫作用机制研究进展
- Author:
Long LI
1
;
Zhifeng TANG
2
;
Wenjing SONG
1
;
Fangyi CHEN
1
;
Yuting YUE
1
;
Xia YANG
3
;
Zhigang WANG
3
;
Wanxin ZHU
1
;
Shengfang WAN
1
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Tianshui Hospital of Integrated Traditional Chinese and Western Medicine， Tianshui 741020， China
3. Tianshui Hospital of Traditional Chinese Medicine， Tianshui 741000， China
- Publication Type:Journal Article
- Keywords:
diabetic gastroparesis;
traditional Chinese medicine;
Cajal interstitial cells;
inflammatory response;
oxidative stress;
cellular pyroptosis;
signaling pathways
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(17):256-266
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic gastroparesis （DGP） is a common diabetic neuropathy that affects the normal function of gastric motility and emptying. Clinically， it often manifests as abdominal distension， nausea and vomiting， early satiety， dyspepsia， etc. The pathogenesis of DGP is multifactorial， closely related to many factors， such as chronic hyperglycemia， neuropathy， autonomic nervous system disorders， inflammation， and oxidative stress. These factors can interact with each other， leading to delayed gastric emptying and the occurrence of related symptoms. Traditional Chinese medicine （TCM） has significant advantages in the prevention and treatment of DGP， including a long history， remarkable efficacy， individualized treatment， diverse therapeutic formulations， and improvement in the quality of life. Additionally， TCM is known for its low adverse reactions， good tolerance， and multi-targeted effects， making it an important approach in the management of DGP. Previous research has found that the main mechanisms of Chinese medicine in the prevention and treatment of DGP include the regulation of gastrointestinal hormones， inhibition of inflammatory responses， reduction of oxidative stress， enhancement of interstitial cells of Cajal activity， inhibition of pyroptosis， and modulation of related signaling pathways such as stem cell factor （SCF）/cellular growth factor receptor （c-Kit）， adenosine monophosphate-activated protein kinase （AMPK）， Ras homologous genome member A （RhoA）/Rho-associated coiled-coil forming kinase （ROCK）. This article primarily summarized the research progress on Chinese medicine in preventing and treating DGP through the inhibition of inflammatory responses， reduction of oxidative stress， enhancement of interstitial cells of Cajal activity， inhibition of pyroptosis， and regulation of related signaling pathways， aiming to provide a reference and basis for further research on the application value of Chinese medicine in the prevention and treatment of DGP.
