Chaihu Shugansan and Its Modified Formulas in Treatment of Functional Dyspepsia： A Review
10.13422/j.cnki.syfjx.20241996
- VernacularTitle:柴胡疏肝散及其加减方治疗功能性消化不良的研究进展
- Author:
Wei ZHAO
1
;
Yaxi ZHANG
1
;
Yuxuan JIANG
1
;
Jiaqing DAI
1
;
Lifang GUO
2
Author Information
1. Graduate School of Hebei University of Chinese Medicine，Shijiazhuang 050091，China
2. Hebei Provincial Hospital of Traditional Chinese Medicine，Shijiazhuang 050017，China
- Publication Type:Journal Article
- Keywords:
Chaihu Shugansan;
functional dyspepsia;
gastrointestinal motility;
pro-inflammatory cytokines;
intestinal flora
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(17):248-255
- CountryChina
- Language:Chinese
-
Abstract:
Chaihu Shugansan composed of Bupleuri Radix， Paeoniae Radix Alba， Chuanxiong Rhizoma， Aurantii Fructus， Citri Reticulatae Pericarpium， Cyperi Rhizoma， and Glycyrrhizae Radix et Rhizoma has the effects of soothing liver， relieving depression， regulating Qi movement， and relieving pain. It is a classic formula for treating gastric distension recommended by doctors of later ages. This article systematically reviews the clinical application and basic experimental progress of Chaihu Shugansan in the treatment of functional dyspepsia. In modern clinical practice， Chaihu Shugansan and its modified formulas are used to treat functional dyspepsia， and they can be applied in combination with other formulas （Si Junzitang， Jinlingzisan， Zhizhuwan， etc.）， western medicine （domperidone tablets， deanxit， Saccharomyces boulardii， etc.）， traditional Chinese medicine （TCM） acupuncture and other therapies. The results of clinical studies have shown that Chaihu Shugansan and its modified formulas can significantly reduce the Hamilton depression scale （HAMD） score， Hamilton anxiety scale （HAMA） score， and TCM syndrome score， ameliorate the symptoms， improve the quality of life， and decrease the recurrence rate. The experimental pharmacological studies have demonstrated that Chaihu Shugansan can inhibit the autophagy of Cajal interstitial cells， regulate the endoplasmic reticulum stress signaling pathway， and modulate the brain-gut peptide level to improve the gastrointestinal motility. Chaihu Shugansan can inhibit the expression of 5-hydroxytryptamine in the colon tissue and reduce the abdominal withdrawal reflex （AWR） score to improve visceral hypersensitivity. Furthermore， Chaihu Shugansan can lower the levels of pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor-α to repair duodenal mucosal inflammation. In addition， it can regulate intestinal flora to maintain intestinal flora balance. The main active ingredients such as saikosaponin， paeoniflorin， hesperidin， and naringin in Chaihu Shugansan can exert anti-inflammatory， antioxidant， and antimicrobial effects.
