Mechanism of Alzheimer's Disease Based on Correlations between Aquaporins and Aromatic Chinese Medicines
10.13422/j.cnki.syfjx.20241895
- VernacularTitle:基于水通道蛋白与芳香类中药相关性探讨阿尔茨海默病机制
- Author:
Senlin CHEN
1
;
Sai'e HUANG
2
;
Zhichen WANG
1
;
Yan LI
3
;
Shixiang KUANG
3
Author Information
1. Fujian University of Traditional Chinese Medicine（TCM），Fuzhou 350122，China
2. Fujian Key Laboratory of Cognitive Rehabilitation，Fuzhou 350003，China
3. The Second Affiliated Hospital of Guizhou University of TCM，Guiyang 550003，China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
aquaporins （AQPs）;
aromatic Chinese medicines;
aromatherapy;
phlegm， dampness， stasis， and toxin
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(17):227-238
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease （AD） is an age-related neurodegenerative disease that belongs to the category of dementia in traditional Chinese medicine （TCM）. According to the TCM theory， phlegm， dampness， stasis， and toxin are the major factors inducing the occurrence and development of AD. The application of aromatic Chinese medicines to remove the combined phlegm， dampness， stasis， and toxin is an important TCM method for treating AD. Aquaporins （AQPs） are involved in the water metabolism of the central nervous system （CNS）， playing a role in the water balance of CNS. Therefore， AQPs are deeply involved in the occurrence and development of AD. AQPs may be the key targets of a variety of aromatic Chinese medicines. From the intrinsic relationship between AQPs and AD-inducing factors （phlegm， dampness， stasis， and toxin）， this study explores the modern medical connotation of treating AD with aromatic Chinese medicines， aiming to provide ideas for the prevention and treatment of AD with TCM.
