Protein Modification Omics： A Novel Approach Investigating Mechanisms of Chinese Medicines
10.13422/j.cnki.syfjx.20240807
- VernacularTitle:蛋白质修饰组学—中药作用机制研究的新途径
- Author:
Lihan WANG
1
;
Jingyi HOU
1
;
Jingjing ZHANG
2
;
Hongjun YANG
1
Author Information
1. Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases，Experimental Research Center，China Academy of Chinese Medical Sciences， Beijing 100700，China
2. Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
post-translational modification;
protein modification omics;
Chinese medicine;
research strategy;
elucidation of complex mechanisms
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(17):211-219
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine （TCM）， as an invaluable scientific legacy and cultural patrimony of China， encapsulates the cumulative wisdom of millennia from the Chinese civilization. The deeply rooted medical theories and extensive empirical practices of TCM hold an indispensible central role within China's healthcare framework. Facing the challenges of modern medicine and health needs， it is particularly urgent to explore the mechanisms of Chinese medicines. Post-translational modification （PTM）， as a core mechanism to regulate the complex and diverse protein functions， is a bridge between environmental stimuli and physiological responses. Different PTMs can interact with each other to form a complex regulatory network， which is in line with the multi-component and multi-target action of Chinese medicines. In recent years， protein modification omics has emerged as a powerful means to probe into PTMs， and studies have employed protein modification omics to investigate the mechanisms of Chinese medicines. However， the research in this field is still in the initial stage. This article summarizes the basic theory of PTM and the basic research process of protein modification omics， reviews the application status of protein modification omics in the research on the mechanisms of Chinese medicines， and analyzes the existing research limitations. This study aims to explore an innovative research paradigm for analyzing the mechanisms of Chinese medicines from the perspective of PTM and provide a theoretical basis and practical guidance for understanding the mechanisms of Chinese medicines in the future.
