The relationship between baseline blood pressure and 3 months outcome of early antihypertensive therapy in acute ischemic stroke
10.19845/j.cnki.zfysjjbzz.2021.0009
- VernacularTitle:基线血压水平与急性缺血性脑卒中早期降压治疗3个月结局的关系
- Author:
Dongyue LI
1
,
2
;
Qunwei LI
1
,
2
;
Yan KONG
1
,
2
Author Information
1. Department of encephalopathy,Tai&rsquo
2. an traditional Chinese medicine hospital,Tai an 271000,China
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Hypertension;
Antihypertensive therapy;
Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the outcome relationship between the baseline blood pressure level and the early antihypertensive therapy of acute ischemic stroke for 3 months. Methods A total of 828 patients who were admitted to hospital within 48 hours of onset and diagnosed with acute ischemic stroke with hypertension through imageological examination from August 2009 to May 2013 were collected. They were divided into 140～160 mmHg group (n=276),160～180 mmHg group (n=350),180～200 mmHg group (n=158),and 200～220 mmHg group (n=44) according to the level of systolic pressure at the time of enrollment,and given randomly or not given antihypertensive therapy. For the patients receiving the antihypertensive therapy,the blood pressure was reduced by 10%～20% within 24 hours,the systolic pressure and diastolic pressure were lower than 140 mmHg and 90 mmHg respectively at 7 days,and maintained at this level for 2 weeks. For the patients not receiving the antihypertensive therapy,antihypertensive drugs were discontinued or not given,and all patients were measured,with the blood pressure levels recorded. The mortality and good prognosis rate were compared at 3 months after discharge. Results Through 3 months of follow-up,the mortality of patients with antihypertensive therapy in the 140～160 mmHg group was significantly higher than that of those without antihypertensive therapy (13.7% vs 5.8%,P<0.05),the good prognosis rate was significantly lower than that of those without antihypertensive therapy (65.5% vs 77.4%,P<0.05),there was no statistically significant difference in mortality and all-cause mortality between 160～180 mmHg group,180～200 mmHg group,and 200～220 mmHg group (9.2% vs 13.4%,11.8% vs 12.3%,13.6% vs 9.1%,P>0.05),and the difference in good prognosis rate was not statistically significant (71.8% vs 62.6%,69.4% vs 60.3%,54.5% vs 59.1%,P>0.05). Conclusion Patients with acute ischemic stroke should not receive antihypertensive therapy when blood pressure is elevated mildly (SBP 140～160 mmHg);the impact of antihypertensive therapy on 3-month outcome is neutral in case of moderate to high blood pressure elevation (SBP 160～220 mmHg).
- Full text:2024073100105749023The relationship between baseline blood pressure and 3 months outcome of early antihypertensive therapy in acute ischemic stroke.pdf
