Risk factors of hemorrhagic transformation and prognosis in patients with acute cerebral infarction and intravenous thrombolysis
10.19845/j.cnki.zfysjjbzz.2021.0008
- VernacularTitle:急性脑梗死静脉溶栓患者出血转化及预后的危险因素研究
- Author:
Yanlong DUAN
1
;
Chunyang ZHANG
1
;
Qiuyan SHI
1
Author Information
1. Department of Neurology,Affiliated Hospital of North China University of Technology,Tangshan 063000,China
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Intravenous thrombolysis;
Hemorrhagic transformation;
Step-down
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(1):36-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of hemorrhagic transformation and prognosis of acute ischemic stroke (AIS) after intravenous thrombolysis. Methods From June 2017 to June 2019,211 patients with AIS undergoing intravenous thrombolysis were selected as the research object. Among them,34 patients with hemorrhagic tromsformation (HT) were recorded as HT group,and 177 patients without hemorrhagic transformation The patient was recorded as a non-HT group,with a bleeding conversion rate of 16.11%. The relationship between intensive blood pressure reduction and bleeding conversion and prognosis in patients with AIS intravenous thrombolysis was analyzed during intravenous thrombolysis. Results Univariate analysis revealed gender,age,time interval between onset to start of treatment (OTT),blood glucose at admission,baseline blood pressure,and baseline from the onset to start of treatment (reombinant tissue plasminogen activator,rt-PA) The National Institute of Health stroke scale (NIHSS) score,type 2 diabetes,atrial fibrillation,and venous thrombolysis have statistically significant differences (P<0.05 or P<0.01),which is a vein Risk factors related to HT after thrombolysis;binary logistic analysis showed that the baseline NIHSS score of 17.5 was divided into independent risk factors for the transformation of venous thrombolysis hemorrhage in AIS patients (OR=1.639,P=0.013). Atrial fibrillation (OR=9.129,P<0.01) is an independent risk factor for the prognosis of patients with intravenous thrombolysis. Conclusion The baseline NIHSS score of 17.5 is divided into independent risk factors for HT after intravenous thrombolysis in AIS patients,and intensive blood pressure reduction during intravenous thrombolysis is a related risk factor for HT;atrial fibrillation is an independent risk factor for the prognosis of patients with intravenous thrombolysis.
- Full text:2024073100084359066Risk factors of hemorrhagic transformation and prognosis in patients with acute cerebral infarction and intravenous thrombolysis.pdf
