Analysis of bleeding characteristics and risk factors caused by aspirin combined with ticagrelor in the treatment of IS/TIA
10.19845/j.cnki.zfysjjbzz.2021.0006
- VernacularTitle:阿司匹林联合替格瑞洛治疗IS/TIA导致的出血特征及危险因素分析
- Author:
Hongjiao TIAN
1
;
Guangqing DU
1
Author Information
1. Department of Pharmacy,Beijing Rehabilitation Hospital of Capital Medical University,Beijing,100144,China
- Publication Type:Journal Article
- Keywords:
Aspirin;
Ticagrelor;
Ischemic stroke;
Transient Ischemic Attack;
Bleeding;
Risk factors
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate characteristics of bleeding caused by combination of aspirin with ticagrelor in the treatment of Ischemic stroke (IS) and Transient Ischemic Attack (TIA),and analyze the risk factors influencing the occurrence of bleeding. Methods 501 patients with IS and TIA who were treated with aspirin combined with ticagrelor were included. And baseline and clinical data of the subjects were collected on the first day after admission,and the occurrence of bleeding events within one year was followed up. Patients were divided into two groups according to whether there was bleeding. Baseline and clinical data of the two groups were compared,and risk factors of bleeding events were analyzed by logistic regression. Results After 1 year of follow-up,a total of 89 patients were found to have bleeding,with a total bleeding rate of 17.76%,a fatal bleeding rate of 5.39% and a non-fatal bleeding rate of 12.38%. In 5.19% of patients,ticagrelor was discontinued due to bleeding,while in 7.58% of patients,the dosage of ticagrelor was halved due to bleeding. Logistic regression analysis found that age,smoking history,history of myocardial infarction,history of peptic ulcer and CRUSADE score≥41 are risk factors for bleeding events (P<0.05). Conclusion 17.76% of IS and TIA had bleeding events during aspirin combined with ticagrelor,and age,smoking history,history of myocardial infarction,history of peptic ulcer disease,and higher CRUSADE score were risk factors for bleeding.
- Full text:2024073100043628844Analysis of bleeding characteristics and risk factors caused by aspirin combined with ticagrelor in the treatment of IS_TIA.pdf
