Repair effect of curcumin on injured neurons in Parkinson’s disease model rats and its related mechanism
10.19845/j.cnki.zfysjjbzz.2021.0030
- VernacularTitle:姜黄素对帕金森模型大鼠损伤神经元的修复作用及相关机制研究
- Author:
Sen GUO
1
;
Shuo ZHANG
1
;
Huixiao FU
1
Author Information
1. Chengde Medical University,Chengde 067000,China
- Publication Type:Journal Article
- Keywords:
Parkinson;
Curcumin;
Neuronal injury;
Inflammatory reaction
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(2):128-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the repair effect of curcumin on injured neurons in Parkinson’s model rats and the related mechanisms.Methods Forty SD healthy male rats were selected,10 were group,the remaining 30 were established Parkinson’s model,divided into model group,low and high dose groups,and the four groups of rats were intervened separately.The learning and memory abilities of rats in each group were tested.HE staining was performed on brain tissue specimens of rats in each group.The size and number of neurons were counted.The levels of IL-6,IL-1β and TNF-α were detected by enzyme-linked immunosorbent assay.Results Compared with model group and low dose group,the size and number of neurons in high dose group were higher (P<0.05).Compared with model group and low dose group,rats in high dose group had shorter escape latency and higher number of times crossing the platform at each time point (P<0.05).Compared with model group and low dose group,the levels of IL-6,IL-1β and TNF-α were lower in high dose group (P<0.05).Conclusion Intervention with curcumin in Parkinson’s model rats can improve the learning and memory ability of rats,increase the size and number of neurons in rat brain tissue,and play a role in neuronal damage repair.Its function may be related to alleviating the inflammatory response in brain tissue,regulating the expression of apoptosis protein.
- Full text:2024073023343814268姜黄素对帕金森模型大鼠损伤神经元的修复作用及相关机制研究.pdf
