Correlation between serum uric acid and homocysteine levels in Parkinson’s disease
- VernacularTitle:帕金森病与血清尿酸、同型半胱氨酸水平的相关性研究
- Author:
Tai WANG
1
;
Changhe SHI
1
;
Chengyuan MAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson’s disease; Uric acid; Homocysteine; Cognitive impairment
- From: Journal of Apoplexy and Nervous Diseases 2021;38(2):117-121
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the correlation between serum uric acid and homocysteine levels in Parkinson’s disease (PD)，as well as the relationship between serum uric acid and homocysteine levels with cognitive impairment,clinical subtypes，different disease stages in PD.Methods One hundred and fourteen patients with Parkinson’s disease and 123 healthy controls were included.Detailed baseline data were collected and patients with Parkinson’s disease were evaluated and grouped by Hoehn and Yahr、MDS-UPDRS and MMSE scale.Serum uric acid and homocysteine levels were measured and compared in all subjects.Results The serum uric acid level of PD group was significantly lower than that of the control group［（241.2±60.8）μmol/L vs （271.2±55.7）μmol/L，P＜0.05］.The serum homocysteine level of PD group was significantly higher than that of the control group［（16.11±6.01）μmol/L vs (12.41±2.94) μmol/L，P＜0.05］.In PD group,serum uric acid level of patients with cognitive impairment was significantly lower than that of patients without cognitive impairment ［（22457.94）μmol/L vs （248.560.96）μmol/L，P＜0.05］,and there was no statistically significant difference between clinical subtypes and different disease stages in PD.Conclusion Compared with the normal control group,serum uric acid level was significantly decreased in PD group,serum homocysteine level was significantly increased in PD group.In PD group,serum uric acid level was significantly lower in patients with cognitive impairment.
- Full text:2024073023245455424帕金森病与血清尿酸、_同型半胱氨酸水平的相关性研究.pdf
