Expression of miRNA-153 and miRNA-223 in serum of patients with Parkinson’s disease
- VernacularTitle: 帕金森病患者血清中miRNA-153和miRNA-223的表达研究
- Author:
Yandong SHAN
1
;
Xiaoyun ZENG
1
;
Zhixiu LUO
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson’s disease ； miRNA-153 ； miRNA-223 ； Biomarkers
- From: Journal of Apoplexy and Nervous Diseases 2021;38(3):233-236
- CountryChina
- Language:Chinese
- Abstract: ObjectiveTo explore the expression levels of miRNA-153 and miRNA-223 in the serum of patients with Parkinson’s disease（PD）and their clinical value，as well as the correlation between the expression of miRNA-153 and miRNA-223 in the serum of PD patients and Hoehn-Yahr（H-Y）scales. 〖WTHZ〗Methods〖WTBZ〗The relative expression levels of serum miRNA-153 and miRNA-223 in 35 patients with PD（PD group）and 40 healthy people（healthy control group）were quantitatively detected. The H-Y scales of PD patients were evaluated. The results were analyzed. 〖WTHZ〗Results〖WTBZ〗The relative expression levels of serum miRNA-153 in PD group were significantly lower than that in healthy control group（t=5.71；P<0.01）. The relative expression levels of serum miRNA-223 in PD group were also significantly lower than that in healthy control group（t=6.07；P<0.01）. There was a negative correlation between the relative expression levels of serum miRNA-153 and H-Y scales in PD group（r=-0.4504，P<0.01）. 〖WTHZ〗Conclusion〖WTBZ〗Serum miRNA-153 and miRNA-223 may be used as biomarkers for the diagnosis of PD；serum miRNA-153 may become an indicator for evaluating the progress of PD.
- Full text:2024073016252190670帕金森病患者血清中miRNA-153和miRNA-223的表达研究.pdf
