Morphological mechanism of reversibly increased vascular permeability of Ioversol to the blood-brain barrier
- VernacularTitle: 碘佛醇可逆性影响大鼠血脑屏障通透性的形态学机制
- Author:
Heying WANG
1
;
Yating JIAN
1
;
Lili ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Cerebral arterial thrombosis ； Vascular risk events ； Vaspin ； Risk factors ； Predictive value
- From: Journal of Apoplexy and Nervous Diseases 2021;38(3):201-204
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the morphological mechanism of contrast-induced encephalopathy（CIE）by observing the effect of ioversol on blood-brain barrier（BBB）in rats. MethodsA total of 42 Sprague-Dawley rats were randomly divided into normal control group（n=6），ioversol group（n=24）and normal saline group（n=12）. The latter two groups were divided into four subgroups based on time points after treatment（0.5 h，3 h，6 h，and 24 h）. Carotid injection of ioversol was to prepare a rat model of brain damage. BBB permeability was examined by an Evans Blue（EB）assay. BBB ultrastructural changes were observed via transmission electron microscopy（TEM）. ResultsCompared with the normal group，there was no significant change in EB content in brain at 0.5 h after the administration of ioversol，while other groups were significantly higher（both P<0.05）. EB content increased at first and then decreased with time，and the highest level was found in 6 h group. The morphology of vascular endothelial cells changed and the structure of tight junctions（TJs）was incomplete in 3 h and 6 h groups，but the ultrastructure of BBB in 0.5 h and 24 h groups had no obvious change compared with the normal group. ConclusionBBB permeability and ultrastructure of rats at different time points after carotid injection of ioversol showed consistent reversible changes，and this dynamic change of BBB was related to the structural changes of TJs.
- Full text:2024073015592685081Morphological mechanism of reversibly increased vascular permeability of Ioversol to the blood-brain barrierWANG Heying.pdf
