Effect of Fingomod on the Inflammatory Response of Cerebral Ischemia-reperfusion Injury in Rats
- VernacularTitle: 芬戈莫德预处理对局灶性脑缺血再灌注大鼠脑组织炎症反应的影响
- Author:
Na LI
1
;
Lei ZHANG
1
;
Jiannan WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Spinal cord injury； Epidermal growth factor receptor ；Osimertinib； BBB score ； GAP-43
- From: Journal of Apoplexy and Nervous Diseases 2021;38(3):196-200
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effect of Fingomod（FTY720）on the cerebral ischemia-reperfusion injury in rats. Methods SPF rats（250 g～300 g）of 8 weeks old were divided into sham operation group，blank control group，group of Clopidogrel and group of FTY720.Rat model of ischemic stroke was made by tMCAO. The behavioral disorder scores were scored in different groups after different drug treatments. And observing the area of infarctus tissue by the TTC method and the nerve cells changed by HE method in different groups. The levels of inflammatory factors IL-1β and IL-6 in brain tissue of rats were changed by method of ELISA. The level of p-p38MAPK and NF-κB in brain tissue of rats were determined by Western-blot method. Results（1）FTY720 can alleviate the behavior disorder of rats（P<0.01）；（2）FTY720 can reduce the area of infarctus tissue（P<0.01）and the injury of neurology cells in rats；（3）FTY720 can reduce the level of p-p38MAPK and NF-κB（P<0.01）in the ischemic brain tissue of rats；4，FTY720 can be reduced The level of IL-1β（P<0.01）and IL-6（P<0.01）in the ischemic brain tissue. Conclusion Fingomod（FTY720）has a protective effect on the cerebral ischemia-reperfusion rat model by decreasing the level of inflammatory response.
- Full text:2024073015253887669Effect of Fingomod on the Inflammatory Response of Cerebral Ischemiareperfusion Injury in Rats.pdf
