Prevalence and risk factors of cerebral small vessel disease neuroimaging markers:a Shanghai community cohort study
10.19845/j.cnki.zfysjjbzz.2021.0077
- VernacularTitle:上海社区队列脑小血管病影像标志物发现率及其危险因素的研究
- Author:
Yiqing WANG
1
;
Yiwei XIA
1
;
Shufan ZHANG
1
Author Information
1. Department of Neurology Huashan Hospital,Shanghai 200040,China
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel disease;
Community cohort;
Neuroimaging markers;
Risk factors
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(4):296-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence,age distribution and risk factors of cerebral small vessel disease (CSVD) neuroimaging markers in Shanghai elderly community population.Methods From August 2016 to October 2019,subjects aged above 50 years and qualified for the study were enrolled from Jingan,Qingpu and Minghang districts in Shanghai.Uniformly designed clinical research forms,neuropsychological assessment,laboratory tests and MRI were performed to gather information and to analyze the prevalence,severity and distribution of lacune,white matter hyperintensity (WMH),cerebral microbleed (CMB) and perivascular space (PVS).Associations between risk factors and neuroimaging markers were analyzed by multivariate logistic regression models.Results Among 870 enrolled subjects who had undergone MRI,median age was 68 years and 40.2% male.Lacune,WMH (Fazekas≥2),CMB and PVS were detected in 17.6%,29.4%,27.8%,96.5% of subjects respectively.With every 10 years’increase in age,there was a 35% increase in lacune,126% increase in WMH and 51% increase in CMB.Compared with non-hypertensive subjects,hypertensive subjects had a 1.98-fold of risk detecting lacune on MRI,while a 1.64,1.91,1.45 fold of risk for WMH,CMB and PVS.ConclusionsAge and hypertension are the major risk factors for CSVD in elderly community population.Age-stratified prevalence of single imaging marker and total CSVD score may have a clinical significance in diagnosing CSVD.
- Full text:2024073012592211148Prevalence and risk factors of cerebral small vessel disease neuroimaging markers_a Shanghai community cohort study.pdf
