ABO blood group screening results among blood donors in Guangzhou from 2021 to 2022
10.13303/j.cjbt.issn.1004-549x.2024.04.011
- VernacularTitle:2021—2022年广州地区献血人群ABO血型筛查结果分析
- Author:
Xuying LIU
1
;
Boquan HUANG
1
;
Fenfang LIAO
1
;
Zhongping LI
1
;
Haojian LIANG
1
;
Rongsong DU
1
;
Junmou XIE
1
;
Aiqiong HUANG
1
;
Hao WANG
1
Author Information
1. Guangzhou Blood Center, Guangzhou 510095, China
- Publication Type:Journal Article
- Keywords:
ABO blood group;
RhD blood group;
discrepancy between forward and reverse blood grouping;
voluntary blood donors
- From:
Chinese Journal of Blood Transfusion
2024;37(4):439-443
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the distribution of ABO and RhD blood groups among voluntary blood donors in Guangzhou, in order to ensure clinical blood safety and better serve blood donors. 【Methods】 Routine ABO and RhD blood group screening tests were carried out among voluntary blood donors from January 2021 to December 2022. The composition ratio of ABO blood group was statistically analyzed. The samples with discrepancy between forward and reverse blood grouping and negative RhD blood group samples were further verified by serological test to analyze the ABO subtypes and the reasons for missed detection. 【Results】 A total of 749 123 blood samples were screened from January 2021 to December 2022, and 513 291 samples were collected after excluding repeat blood donors, with the ABO blood groups as 208 126(40.55%) of O type, 138 859(27.05%) of A type, 130 987(25.52%) of B type and 35 319(6.88%) of AB type. The screening results showed discrepancy between forward and reverse blood grouping in 506 samples, of which 58 were with weak/non-erythrocyte reaction, 16 with erythrocyte reaction, 215 with weak/non-serum reaction, and 217 with serum reaction. Further serological test indicated that 44 samples were ABO subtypes, among which 13 were subtype A, 26 subtype B, 5 subtype AB and 3 B (A) and 14 Bombay-like blood group. The blood group with the highest missed detection rate in repeat blood donors were A3/B3 subtype (68.42%). A total of 128 unexpected antibody positive samples were detected among 513 291 samples A total of 2 277 samples were screened negative for RhD blood type, of which 2 188 were confirmed to be Rh negative (2 188/513 291, 0.43%), 89 were D variants (89/513 291, 0.02%, ) and 30 were detected with unexpected antibodies (30/2 188, 1.37%). 【Conclusion】 The ABO blood group distribution of blood donors in Guangzhou is O>A>B>AB, and the proportion of RhD negative population is 0.43%, slightly highter than 0.3%-0.4% of Han population nationwide. The ABO blood group subtype is dominated by B subtype. The detection rate and missed detection rate of A3/B3 subtypes in routine blood group tests are the highest.
