New hope for clinical blood transfusion:xenotransfusion based on gene-edited pigs

VernacularTitle:临床输血的新希望:基于基因编辑猪的异种输血
Author: Mengyi CUI ¹ ; Leijia CHEN ; Yuanyuan LI ; Kai WANG ; Shengfeng CHEN ; Boyao YANG ; Xiangyu SONG ; Zhibo JIA ; Haochen ZUO ; Wenjing XU ; Jiang PENG
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1. 解放军总医院第四医学中心骨科医学部研究所,骨科战创伤实验室,骨科再生医学北京市重点实验室,北京 100853
Keywords: xenotransfusion; genetically modified pigs; immunological rejection; porcine red blood cells
From: Chinese Journal of Blood Transfusion 2024;37(5):607-612
CountryChina
Language:Chinese
Abstract: Although blood banks based on human blood can provide blood transfusions for the wounded timely and effec-tively,scientific research has never given up on finding new blood sources due to the restrictions of human blood sources.With the application of transgenic technology and the successful breeding of gene-edited pigs,gene-edited pig blood as a po-tential source of clinical transfusion has attracted wide attention.Now there are preclinical studies showing the feasibility of transfusing gene-edited pig red blood cells into primates.This paper discusses the related research and future development of xenogeneic transfusion of porcine red blood cells by gene editing.