Adverse reactions of apheresis plasma donation in 27 domestic plasma donation stations
10.13303/j.cjbt.issn.1004-549x.2024.05.014
- VernacularTitle:国内27家浆站单采血浆捐献不良反应调查情况
- Author:
Yang GAO
1
;
Yumeng SU
;
Hong ZHANG
;
Demei DONG
Author Information
1. 北京天坛生物制品股份有限公司,北京 100000
- Keywords:
plasma donors;
adverse reactions of plasma donation;
age;
apheresis plasma donation
- From:
Chinese Journal of Blood Transfusion
2024;37(5):575-579
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics and influencing factors of adverse reactions of apheresis plasma do-nation in 27 domestic plasma donation stations,and put forward targeted preventive measures.Methods A total of 6 275 plasma donors with adverse reactions from 2018 to 2020 in 27 plasma donation stations in China were selected as the re-search objects.The types of adverse reactions,ages,time of plasma donation and other related characteristics were counted and retrospectively analyzed.Results From January 2018 to December 2020,the incidence of adverse reactions of aphere-sis plasma donation in 27 plasma collection stations was 1.37‰,including vasovagal reaction/hypovolemia(3 208 cases,0.700‰),sodium citrate allergy/hypocalcemia(1 205 cases,0.263‰),hypoglycemia(1 020 cases,0.223‰),syncope(796 cases,0.174‰),hematoma(8 cases,0.002‰),other reactions(36 cases,0.008‰),all of which were non-se-vere adverse reactions.There were significant differences in the incidence of different types of adverse reactions(P＜0.001).The adverse reactions in 2018,2019 and 2020 were compared,and the difference was statistically significant(P＜0.001),with the highest incidence of 1.51‰(2 143/1 414 162)of adverse reactions in 2019 and the lowest incidence of 1.29‰(1 818/1 410 506)in 2020.The difference in the incidence of adverse reactions in different age groups was statistically sig-nificant(P＜0.001),with the highest incidence of 2.61‰(224/85 733)of 18-25 years old,and the lowest incidence of 1.05‰(465/439 786)of 56-60 years old.The incidence of different types of adverse reactions was compared according to different age groups,and significant differences were noticed in the incidence of vasovagal reaction/hypovolemia(P＜0.001),sodium citrate allergy/hypocalcemia(P＜0.05),hypoglycemia(P＜0.001),and syncope(P＜0.001)among dif-ferent age groups,while no significant difference was found in hematoma and other adverse reactions among different age groups(P＞0.05).Conclusion The incidence of adverse reactions in plasma donation is low in China.In the process of plasma donation,attention should be paid to first-time and young(18-25 years old)donors.The incidence of adverse reac-tions in 56-60 years old donors is the lowest,which can provide data support for the age revision of plasma donors in China.
