Adverse reactions of apheresis plasma donation in 27 domestic plasma donation stations
10.13303/j.cjbt.issn.1004-549x.2024.05.014
- VernacularTitle:国内27家浆站单采血浆捐献不良反应调查情况
- Author:
Yang GAO
1
;
Yumeng SU
1
;
Hong ZHANG
2
;
Demei DONG
1
Author Information
1. Beijing Tiantan Biological Products Co., Ltd, Beijing 100000, China
2. Sinopharm XI′AN Biopharmaceuticals Co., Ltd.
- Publication Type:Journal Article
- Keywords:
plasma donors;
adverse reactions of plasma donation;
age;
apheresis plasma donation
- From:
Chinese Journal of Blood Transfusion
2024;37(5):575-579
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the characteristics and influencing factors of adverse reactions of apheresis plasma donation in 27 domestic plasma donation stations, and put forward targeted preventive measures. 【Methods】 A total of 6 275 plasma donors with adverse reactions from 2018 to 2020 in 27 plasma donation stations in China were selected as the research objects. The types of adverse reactions, ages, time of plasma donation and other related characteristics were counted and retrospectively analyzed. 【Results】 From January 2018 to December 2020, the incidence of adverse reactions of apheresis plasma donation in 27 plasma collection stations was 1.37‰, including vasovagal reaction/hypovolemia (3 208 cases, 0.700‰), sodium citrate allergy/hypocalcemia (1 205 cases, 0.263‰), hypoglycemia (1 020 cases, 0.223‰), syncope (796 cases, 0.174‰), hematoma (8 cases, 0.002‰), other reactions (36 cases, 0.008‰), all of which were non-severe adverse reactions. There were significant differences in the incidence of different types of adverse reactions (P<0.001).The adverse reactions in 2018, 2019 and 2020 were compared, and the difference was statistically significant (P<0.001), with the highest incidence of 1.51‰(2 143/1 414 162) of adverse reactions in 2019 and the lowest incidence of 1.29‰(1 818/1 410 506) in 2020. The difference in the incidence of adverse reactions in different age groups was statistically significant (P<0.001), with the highest incidence of 2.61‰(224/85 733) of 18-25 years old, and the lowest incidence of 1.05‰(465/439 786) of 56-60 years old. The incidence of different types of adverse reactions was compared according to different age groups, and significant differences were noticed in the incidence of vasovagal reaction/hypovolemia (P<0.001), sodium citrate allergy/hypocalcemia (P<0.05), hypoglycemia (P<0.001), and syncope (P<0.001) among different age groups, while no significant difference was found in hematoma and other adverse reactions among different age groups (P>0.05). 【Conclusion】 The incidence of adverse reactions in plasma donation is low in China. In the process of plasma donation, attention should be paid to first-time and young (18-25 years old) donors. The incidence of adverse reactions in 56-60 years old donors is the lowest, which can provide data support for the age revision of plasma donors in China.
