Changes in perioperative blood group antibody of 33 type-A/B recipients in ABO-incompatible kidney transplantation
10.13303/j.cjbt.issn.1004-549x.2024.05.008
- VernacularTitle:33例非O型ABOi肾移植受者围术期血型抗体的变化
- Author:
Huifang JIN
1
;
Yongkui KONG
1
;
Xin LIU
1
;
Shuya WANG
1
;
Liyinghui CHEN
1
;
Hao YANG
1
;
Jinfeng LI
2
;
Qiankun YANG
1
Author Information
1. Department of Blood Transfusion, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
2. Department of Renal Transplantation, the First Affiliated Hospital of Zhengzhou University
- Publication Type:Journal Article
- Keywords:
ABO-incompatible kidney transplantation;
plasma exchange;
antibody titer;
perioperative period
- From:
Chinese Journal of Blood Transfusion
2024;37(5):534-540
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To statistically analyze the perioperative results of patients with ABO-incompatible kidney transplantation (ABOi-KT), in order to explore the changes in blood group antibody of type-A/B recipients. 【Methods】 A total of 33 cases of blood group A/B ABOi-KT recipients in our hospital from January 2021 to October 2023 were recruited and divided into two groups of group A(n=18) and group B(n=15) according to the different blood types of recipient. The effects of preoperative plasmapheresis on antibody titer, antibody rebound and renal function after operation(serum urea nitrogen, creatinine and estimated glomerular filtration rate on the 1st, 3rd, 7th and 14th day) were analyzed between the two groups. According to the postoperative rebound of blood type antibodies, 33 recipients were divided into antibody rebound group(n=7) and non rebound group(n=26), and the differences in initial blood type antibody titers between the two groups were analyzed. 【Results】 There was no significant difference in the clearance rate of IgM with preoperative plasma exchange between the two groups (Z=-0.26, P>0.05); Levels of serum urea nitrogen and creatinine on the 1st, 3rd, 7th and 14th day after operation between group A and group B were not statistically significant(P>0.05), the same as eGFR. Group B was more prone to rebound antibody compared with group A (P<0.05). There was a significant difference in the initial IgM antibody titer between the blood type antibody rebound group and the non rebound group (Z=-2.127, P<0.05), but no statistically significant difference in the initial IgG antibody titer (Z=-1.835, P>0.05) between the two groups was found. 【Conclusion】 The patients type B receiving type AB kidney donors are more prone to rebound antibody after ABOi-KT operation compared to the the patients type A receiving type AB.
