Cases report and diagnosis and treatment of passenger lymphocyte syndrome after liver and renal transplantation
10.13303/j.cjbt.issn.1004-549x.2024.05.002
- VernacularTitle:肝肾移植术后并发过客淋巴细胞综合征的病例报告及诊疗分析
- Author:
Yuxin HE
1
;
Yiran MA
1
;
Shuang ZHANG
1
;
Jingchun JIN
1
Author Information
1. The First Affiliated Hospital of China Medical University, Shenyang 110000, China
- Publication Type:Journal Article
- Keywords:
liver and renal transplantation;
passenger lymphocyte syndrome(PLS);
case report;
diagnosis and treatment
- From:
Chinese Journal of Blood Transfusion
2024;37(5):495-500
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To summarize the clinical features, serological features, blood transfusion protocols and treatment of 3 cases of passenger lymphocyte syndrome(PLS) after ABO-incompatibility liver and renal transplantation in our hospital, in order to provide guidance for comprehensive clinical understanding and recognition of this disease, especially early recognition and treatment. 【Methods】 By collecting the basic information of the patients and the time of cross-matching incompatibility of homologous blood after transplantation, observing the skin yellow staining, detecting hemoglobin value and other hemolysis indexes, and blood group serological detection results before and after transfusion, the diagnosis and analysis were performed. The diagnosis and treatment effect of PLS were analyzed by collecting the clinical outcome information after immunization and blood transfusion. 【Results】 Three cases of ABO-incompatible liver transplantation showed decreased hemoglobin and hemolysis, incompatible cross-matching of homologous blood, and anti-A and anti-B IgG antibodies were confirmed by serological test. After treatment such as immunosuppression and plasma exchange, blood transfusion was effective, hemolysis was improved, and antibodies gradually disappeared. 【Conclusion】 ABO blood group antibody screening, unexpected antibody screening and direct antiglobulin test(DAT)should be performed regularly for ABO-incompatible liver and renal transplantation cases, in order to detect the PLS early. A series of laboratory tests related to PLS should be performed in time to diagnose and adjust the treatment plan, including transfusion strategy, when homologous cross-matching is incompatible.
