Establishment of reference intervals for serum sTfR and sTfR/lgSF in apparently healthy adults in Wuhan
10.13303/j.cjbt.issn.1004-549x.2024.07.015
- VernacularTitle:武汉地区表观健康成人血清sTfR和sTfR/lgSF参考区间的建立
- Author:
Cuihua TAO
1
,
2
;
Shanshan DONG
3
;
Ru TU
4
;
Ran LI
4
;
Ling LI
3
;
Shuzheng CAO
3
Author Information
1. Department of Transfusion Medicine, Wuhan Aisa General Hospital, Wuhan 430022, China
2. Department of Transfusion Medicine
3. Department of Clinical Laboratory, Wuhan Asia Heart Hospital
4. Department of Transfusion Medicine
- Publication Type:Journal Article
- Keywords:
sTfR;
sTfR/lgSF;
iron deficiency;
reference intervals;
Wuhan
- From:
Chinese Journal of Blood Transfusion
2024;37(7):807-811
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To establish reference intervals for serum soluble transferrin receptor (sTfR) and sTfR/log serum ferritin index (sTfR/lgSF) in apparently healthy adults in the Wuhan area, so as to provide reference for clinical diagnosis and treatment of iron deficiency and iron-deficiency anemia. 【Methods】 A total of 273 individuals from the Wuhan Aisa General Hospital, including health examination participants and blood donors, were selected to measure sTfR, other iron metabolism indicators and high sensitivity C-reactive protein(hsCRP). The sTfR/lgSF values were calculated and reference intervals for sTfR and sTfR /lgSF were established using the percentile method (P2.5 to P97.5). Spearman correlation analysis was used to evaluate the relationships between sTfR, sTfR/lgSF, and other iron metabolism indicators, as well as hsCRP. 【Results】 The sTfR levels (M, mg/L) between males and females (1.01 vs 1.07) were not statistically significant (P>0.05), but the sTfR/lgSF levels if males were significantly lower than those in females (0.45 vs 0.62)(P<0.05). There was no significant difference in sTfR (M, mg/L) and sTfR/lgSF (M) among different age groups, with values of 1.07 vs 1.02 vs 1.00 and 0.52 vs 0.53 vs 0.51, respectively(P>0.05). The reference interval for STfR was (0.72-1.68) mg/L, the sTfR/lgSF reference interval was (0.31-0.88) for males, and (0.37-1.19) for females. Correlation analysis showed no correlation between sTfR, sTfR/lgSF and hsCRP (r=0.043, P>0.05; r=-0.064, P>0.05), while serum ferritin(SF), serum iron(SI), transferrin saturation(TSAT)were correlated with hsCRP (r=0.128, P<0.05; r=-0.195, P<0.01; r=-0.173, P<0.01).There was no correlation between sTfR and SF (r=-0.115, P>0.05), while sTfR/lgSF was significantly correlated with and SF (r=-0.685, P<0.01). 【Conclusion】 Preliminary reference intervals for serum sTfR and sTfR/lgSF in apparently healthy adults in the Wuhan has been established. sTfR and sTfR/lgSF are not affected by inflammatory factors and are significant for identifying iron deficiency in anemia patients with elevated serum ferritin caused by inflammation.
