Impact of therapeutic plasma exchange intervention timing and liver injury periodization on the prognosis of patients with exertional heat stroke
10.13303/j.cjbt.issn.1004-549x.2024.07.002
- VernacularTitle:血浆置换介入时机与肝损伤分期对劳力性热射病患者预后的影响研究
- Author:
Zongzhong HE
1
,
2
;
Min WANG
3
;
Yuan ZHUANG
1
;
Jie LIN
1
;
Leiying ZHANG
1
;
Liyang ZOU
1
;
Lingling LI
1
;
Chunya MA
1
;
Xiaomin LIU
1
;
Xiang QUAN
1
;
Ying JIANG
1
;
Mou ZHOU
4
;
Hongjun KANG
3
;
Yang YU
1
Author Information
1. Department of Blood Transfusion Medicine, The First Medical Center, The General Hospital of PLA, Beijing 100853, China
2. Department of Blood Transfusion Medicine, General Hospital of Southern Theatre Command
3. Department of Critical Care Medicine, The First Medical Centre, The General Hospital of PLA
4. Department of Blood Transfusion Medicine, General Hospital of Southern Theatre Command
- Publication Type:Journal Article
- Keywords:
exertional heat stroke(EHS);
liver injury;
therapeutic plasma exchange
- From:
Chinese Journal of Blood Transfusion
2024;37(7):728-733
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the prognostic impact and clinical application value of therapeutic plasma exchange(TPE) intervention timing and liver injury periodization in patients with exertional heat stroke(EHS). 【Methods】 Data of 127 EHS patients from the First Medical Center of the General Hospital of the People′s Liberation Army from January 2011 to December 2023 were collected, then divided into the death group and the survival group based on therapeutic outcomes and into 5 stages according to the dynamic changes of ALT, AST, TBIL and DBIL. According to propensity score matching analysis, 11 patients in the survival group and 12 patients in the death group were included in the statistical analysis, and 20 of them were treated with TPE. The changes in indicators and clinical outcomes before and after TPE were observed, in order to evaluate the impact of intervention timing on prognosis. 【Results】 Among the 23 patients, 14 had no liver injury or could progress to the repair phase, resulting in 3 deaths(with the mortality rate of 21.43%), while 9 patients failed to progress to the repair phase, resulting in 9 deaths(with the mortality rate of 100%), with significant differences(P<0.05). The mortality rate of the first TPE intervention before the third stage of liver injury was 23.08%(3/13), while that of intervention after reaching or exceeding the third stage was 85.71%(6/7), and the difference was statistically significant(P<0.05). 【Conclusion】 TPE should be executed actively in EHS patients combined with liver injury before the third phase to lock its pathological and physiological processes, thereby improving prognosis and reducing mortality.
