Predictive value of Cystatin C for Early Neurological Deterioration in patients with incipient Acute Cerebral Infarction
- VernacularTitle: 胱抑素C对初发急性脑梗死患者早期神经功能恶化的预测价值
- Author:
Jing LIU
1
;
Qiang LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Cys-C; Acute Cerebral Infarction; Early Neurological Deterioration
- From: Journal of Apoplexy and Nervous Diseases 2021;38(5):441-444
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the predictive value of Cystatin C（Cys-C） for Early Neurological Deterioration（END） in patients with incipient Acute Cerebral Infarction（ACI） that has normal renal function. Methods A total of 243 patients with primary ACI and no chronic kidney disease who were admitted to Department of Neurology，the Third Affiliated Hospital of Jinzhou Medical University from July 2019 to July 2020 were selected. All patients were examined by CT and MR. The patients were divided into END group and non-END group according to the variation of NIHSS score within 72 hours after admission. Compare the general baseline data of the two groups of patients and the laboratory indicators examined for the first time on admission. Determine the factors that may affect the occurrence of END by univariate analysis and multivariate Logistic regression analysis，and analyze the predictive value of Cys-C on the occurrence of the END of ACI by using Receiver Operating Characteristic（ROC） curve.Results Cys-C level of END group was significantly higher than that of non-END group，and the difference was statistically significant（P<0.05）.Logistics regression analysis suggests that Cys-C level is an independent risk factor for the END of ACI. ROC curve showed that the area under the curve of Cys-C for predicting the occurrence of ACI’s END was 0.745［95%CI（0.661，0.828）］，indicating that serum Cys-C had a moderate predictive value for the occurrence of END.The Youden index was 0.385，the predictive critical value was 1.845mg/L，the sensitivity was 65.8%，and the specificity was 72.7%.Conclusion Cys-C has predictive value for the occurrence of END，and the predictive value is relatively high.When the level of Cys-C is higher than 1.845mg/L，the probability of the occurrence of END is the highest.
- Full text:2024072922550372699Predictive value of Cystatin C for Early Neurological Deterioration in patients with incipient Acute Cerebral Infarction.pdf
