Study on the relationship between Neutrophil lymphocyte ratio，platelet lymphocyte ratio and disease activity in patients with neuromyelitis optica spectrum disorders
- VernacularTitle: 视神经脊髓炎谱系病患者中性粒细胞/淋巴细胞比值血小板/淋巴细胞比值与疾病活动的关系
- Author:
Qingli SUN
1
;
Aping SUN
1
;
Yu FU
1
Author Information
- Publication Type:Journal Article
- Keywords: Neurosyphilis; Epilepsy; EEG features
- From: Journal of Apoplexy and Nervous Diseases 2021;38(5):437-444
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the relationship between the neutrophil to lymphocyte ratio（NLR） and the platelet to lymphocyte ratio（PLR） and disease activity in patients with neuromyelitis optica spectrum disorders（NMOSD）.Methods The clinical data，laboratory examination and imaging data of NMOSD patients admitted to Peking University Third Hospital from January 2015 to June 2019 were retrospectively analyzed to calculate the NLR and PLR. The NLR and PLR of 100 healthy subjects were compared.Results A total of 48 patients with NMOSD were enrolled. The white blood cell count，neutrophil absolute value and NLR of NMOSD in attack period were significantly higher than those in remission period and control group，while the lymphocyte absolute value was significantly lower than those in remission period and control group.There was no significant difference in platelet count and PLR between NMOSD group and control group.There were no statistically significant differences in WBC count，neutrophil absolute value，lymphocyte absolute value，platelet count，NLR and PLR between AQP4 Ab（+） patients and AQP4 Ab（-）patients in the NMOSD patients at the onset stage. The area under curve（AUC）the NLR in receiver operating characteristics was 0.806（P=0.000，95%CI 0.734～0.878）.
- Full text:2024072922512580195视神经脊髓炎谱系病患者中性粒细胞_淋巴细胞比值血小板_淋巴细胞比值与疾病活动的关系.pdf
