Study on the relationship between RDW-SD and the risk of recurrent ischemic stroke
- VernacularTitle:外周血红细胞体积分布宽度与缺血性脑卒中复发风险之间的关系研究
- Author:
Zeyuan LI
1
;
Hui DENG
1
;
Yi WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: RDW-SD; Recurrent ischemic stroke; Cumulative risk; U-shaped association
- From: Journal of Apoplexy and Nervous Diseases 2021;38(5):428-436
- CountryChina
- Language:Chinese
- Abstract: Objective To study the relationship between the red blood cell distribution width-standard deviation（RDW SD） and the risk of recurrent ischemic stroke（IS）. Methods We conducted a retrospective case-control study in 187 patients with recurrent IS who were admitted to neurology department of affiliated hospital of Inner Mongolia medical university，the time of first-ever IS and other baseline characteristic were recorded. The relationship between recurrent IS time and RDW-SD was analyzed by polynomial regression analysis. 187 patients were divides into two groups according to the quartile level of RDW-SD. Kaplan-Meier analysis was used to calculate the cumulative risk of recurrent IS in different groups，and log rank method（χ2 test） was used to compare the differences between groups to study the relationship between RDWSD and recurrent IS risk.Results The results from polynomial regression analysis showed that there was a significant U shaped correlation between RDW-SD level and the recurrent IS time，and its regression coefficient was significantly different from 0 at P<0.05.The median RDW-SD of 187 patients with recurrent IS was 41.80 FL.According to the RDW-SD quartile level，187 patients were divided into 2 groups，including 98 patients corresponding to the highest quartile and the lowest quartile（Q1+Q4）and 89 patients corresponding to the second and third quartiles（Q2+Q3）. There was no significant difference in baseline characteristics between the two groups. Kaplan-Meier analysis illustrated that the patients with the first quartile and the firth quartile（Q1+Q4）of RDW SD levels had a significantly increased cumulative risk of recurrent IS compared to patients with middle quartile（Q2+Q3）of RDW-SD levels（Log Rank=5.047，P=0.02），especially for female patients（Log Rank=6.143，P=0.013）.For male patients，the cumulative risk of recurrent IS was higher in patients with Q1+Q4 group than patients in Q2+Q3 group，but no significant difference was found among two groups（Log Rank=1.325，P=0.25）.Conclusion AU shaped association was found between RDW SD levels and the cumulative risk of recurrent IS，especially for female patients.
- Full text:2024072922425222818Study on the relationship between RDWSD and the risk of recurrent ischemic stroke.pdf
