Detection and significance of the level of serum calmodulin and GABA/Glu in insomnia patients
- VernacularTitle: 失眠患者血清钙调蛋白及GABA/Glu水平检测及其意义
- Author:
Ting SU
1
;
Wei GAO
1
;
Huaxin LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Insomnia; Calmodulin; Glu; GABA
- From: Journal of Apoplexy and Nervous Diseases 2021;38(5):407-410
- CountryChina
- Language:Chinese
- Abstract: Objective We detected the level of serum calmodulin，γ-aminobutyric acid（GABA），glutamic acid（Glu） and GABA/Glu in insomnia patients，explored their association with insomnia.Methods The casecontrol study was used. This study comprised 119 insomnia patients and 122 healthy control subjects. Enzyme linked immunosorbent assay（ELISA） was utilized to measure the level of serum CaM，GABA，Glu and GABA/Glu. The correlation between the level of serum CaM and GABA/Glu was performed by correlation analyze. Results Our results suggested the level of serum CaM,GABA,GABA/Glu were significantly lower，and the level of serum Glu was significantly higher in patients with insomnia compared to the control group（P<0.05）.The level of serum CaM was positively correlated with GABA/Glu in insomnia patients（r=0.475，P<0.05）.Conclusion CaM downregulation increases the risk of insomnia，and the mechanism may be related to the downregulation of GABA/Glu level.
- Full text:2024072922354728224Detection and significance of the level of serum calmodulin and GABA_Glu in insomnia patients.pdf
