Association Study Of Novel Risk Loci For Restless Legs Syndrome In Chinese Population
- VernacularTitle: 中国人群原发性不宁腿综合征新风险基因的相关性研究
- Author:
Lei HUANG
1
;
Jie CHEN
1
;
Yumeng HUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Restless legs syndrome ； Genetic association study ； Single nucleotide polymorphism
- From: Journal of Apoplexy and Nervous Diseases 2021;38(5):388-391
- CountryChina
- Language:Chinese
- Abstract: Objective We aimed to examine whether lead single nucleotide polymorphism(SNPs) within novel risk loci were associated with the risk for RLS in Chinese population.Methods A total of 184 RLS patients and 230 controls were enrolled in this study. Polymer chain reaction（PCR） and sequencing were used to detect 20 lead single nucleotide polymorphisms within 19 genetic loci.Results Among the 20 selected lead SNPs,the frequency of the rs365032G allele localized in MYT1 gene was higher in RLS patients（OR=1.36，P=0.032） and contributed to the risk of RLS in the dominant model（GG and GA vs AA） after adjustment for age and sex（OR=1.77，P=0.009）.However,none of these were survived after Bonferroni correction.Conclusion Our study failed to replicate the association between lead SNPs identified in 19 genomic risk loci with RLS in Chinese population. Large scale whole exome sequences,or even whole genome sequencing studies，are certainly needed in the future to investigate possible causative variants across 19 risk loci.
- Full text:2024072922251831124Association Study Of Novel Risk Loci For Restless Legs Syndrome In Chinese Population.pdf
