Risk factors for neuropsychological impairment in patients with sleep-related hypermotor epilepsy
10.19845/j.cnki.zfysjjbzz.2021.0139
- VernacularTitle:睡眠相关过度运动癫痫患者神经心理损害的危险因素
- Author:
Shengsong WANG
1
;
Huijuan WAN
1
;
Wenhan HU
1
Author Information
1. Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China
- Publication Type:Journal Article
- Keywords:
Sleep;
Hypermotor;
Epilepsy;
Neuropsychological;
Risk factors
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(6):522-525
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors for neuropsychological impairment in patients with sleep-related hypermotor epilepsy (SHE).Methods We conducted a retrospective analysis consecutive patient with SHE from the epilepsy center of Tiantan Hospital Affiliated to Capital Medical University and Beijing Fengtai Hospital between May 2015 and May 2019.Patients were divided into two groups:neuropsychological impairment (n=31) and non-neuropsychological impairment (n=37).Patient demographics,clinical data were recorded and analyzed.Multinomial logistic regression analysis was performed to determine the independent risk factors for neuropsychological impairment in patients with SHE.Results We found that patients in the neuropsychological impairment group had a lower age of onset,a higher seizure frequency,a higher proportion of patients with more interictal epileptiform discharges (IEDs) in sleep than in waking periods,and a higher proportion of patients with potential brain disorder,these differences were statistically significant（P<0.05）.Multivariate logistic regression analysis showed that patients with more IEDs in sleep than in waking periods（OR=17.315，95%CI 3.304~90.746，P=0.001）,a higher seizure frequency（OR=7.493，95%CI 1.416~39.665，P=0.018） were independently associated with neuropsychological impairment in patient with SHE.The higher age of onset（OR=0.862，95%CI 0.777~0.957，P=0.005） was protective factors associated with neuropsychological impairment in patient with SHE（P<0.05）.Conclusion The patients with a lower age of onset,a higher seizure frequency,a higher proportion of patients with more IEDs in sleep than in waking periods were independently associated with neuropsychological impairment in patient with SHE.Early identification of related risk factors affecting neuropsychological impairment in patient with SHE have great clinical significance for improving their quality of life.
- Full text:2024072922102598570Risk factors for neuropsychological impairment in patients with sleep-related hypermotor epilepsy.pdf
