Structure Magnetic Resonance Imaging of brain in depressed patients based on voxel-based morphological
- VernacularTitle: 基于体素的形态学方法对抑郁症患者的脑结构磁共振研究
- Author:
Chunmei LIU
1
;
Chunmei WANG
1
;
Lishan WU
1
Author Information
- Publication Type:Journal Article
- Keywords: Depression; Structure magnetic resonance imaging; Voxel-based morphometry
- From: Journal of Apoplexy and Nervous Diseases 2021;38(7):606-608
- CountryChina
- Language:Chinese
- Abstract: Objective Voxel-based morphological analysis was used to explore the changes of gray matter volume in patients with first-episode untreated depression，and to explore the structural changes of brain regions in patients with depression，so as to provide new ideas for in-depth understanding of the pathogenesis of depression.Methods 30 patients with first-episode untreated depression and 22 healthy volunteers were included. Used the PHILPS 3.0T MRI scanner for sagittal three-dimensionl brain structre scans，the brain structure images of the two groups were studied by the VBM method to explore the changes of gray matter volume in patients with first-episode untreated depression.Results Compared to healthy controls，the volume of gray matter in left middle tempral gyrus，right inslar lobe，left supeior occiptal gyrus and right dorsolteral supeior frontal gyrus were decresed in the first-episode untreated depression group（P<0.05，cluster size>45，AlphaSim correction），no region increased.Conclusion The brain regions with decreased gray matter volume in patients with first-episode untreated depression are mainly located in frontal lobe，temporal lobe，occipital lobe and insular lobe，indicating that the occurrence and development of depression is related to multiple brain regions.
- Full text:2024072921181195736Structure Magnetic Resonance Imaging of brain in depressed patients based on voxel-based morphological.pdf
