Early secondary changes and memory impairment of hippocampus after subcortical infarction in middle cerebral artery
10.19845/j.cnki.zfysjjbzz.2021.0183
- VernacularTitle: 大脑中动脉供血区皮质下梗死后海马早期继发性改变与记忆损害研究
- Author:
Xiaojie LIU
1
;
Haina ZHAO
1
;
Beilei CHEN
1
Author Information
1. Department of Neurology,North Jiangsu People Hospital,Yangzhou 225001,China
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
The hippocampus;
Semantic memory;
Diffusion tensor imaging;
Mean diffusivity
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(8):689-692
- CountryChina
- Language:Chinese
-
Abstract:
Abstract
Objective To observe the dynamic changes of hippocampus microstructure in patients with cerebral infarction within the territory of the middle cerebral artery (MCA) with cortex involvement,thus exploring the relationship between these changes and the changes in semantic memory function.Methods Twenty-two patients with acute subcortical infarction were assessed for cognitive function,structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) at 1,4,and 12 weeks (W) respectively.A total of 22 gender and age matched subjects were enrolled as healthy controls.Results Bilateral hippocampal volume did not change significantly during the entire follow-up period.Spearman’s rank correlations showed that percent decreases in immediate recall and long-delay recall scores correlated negatively with percent increases in mean diffusivity (MD) values in the ipsilateral hippocampus (immediate,rs=0.683,P=0.006; long-delay,rs=-0.602,P=0.013).Conclusion In patients with cerebral infarction within the territory of the MCA with cortex involvement,the microstructural integrity of the hippocampus may be damaged before the macrostructure changes,and these changes may be related to the decline of semantic memory.
- Full text:2024072919334652294Early secondary changes and memory impairment of hippocampus after subcortical infarction in middle cerebral artery.pdf
