CCCK-18 and CTRP3 changes in serum of patients with acute ischemic stroke and their clinical significance
10.19845/j.cnki.zfysjjbzz.2021.0182
- VernacularTitle: 急性缺血性脑卒中患者血清CCCK-18、CTRP3水平变化及临床意义
- Author:
Xia LI
1
;
Yanjie CHEN
1
;
Zemin LIU
1
Author Information
1. Department of Neurology,Tangshan People Hospital,Tangshan 063000,China
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Caspase-cleaved cytokeratin-18;
Complement 1q tumor necrosis factor-related protein 3;
Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(8):685-688
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and clinical significance of serum caspase-cleaved cytokeratin-18 (CCCK-18) and complement 1q tumor necrosis factor-related protein 3 (CTRP3) levels in patients with acute ischemic stroke (AIS).Methods A total of 163 AIS patients were selected as the AIS group.According to the National Institutes of Health Stroke Scale (NIHSS),the patients were divided into the mild defect group (49 cases),moderate defect group (76 cases),severe defect group (38 cases),after 3 months of treatment,patients were divided into poor prognosis group (66 cases) and good prognosis group (97 cases) according to the modified Rankin scale (mRS),in addition,72 healthy individuals who had physical examination during the same period were selected as the control group.Enzyme-linked immunosorbent assay was used to determine serum CCCK-18 and CTRP3 levels.Results The serum CCCK-18 level in the AIS group was significantly higher than that in the control group,and the CTRP3 level was significantly lower than that in the control group (P＜0.05).The serum CCCK-18 level in the mild,moderate,and severe defect groups gradually increased,and the CTRP3 level gradually decreased (P＜0.05).The serum CCCK-18 level was positively correlated with NIHSS score,and CTRP3 level was negatively correlated with NIHSS score (P＜0.05).Multivariate logistic regression analysis showed that large area infarction,high NIHSS score,high CCCK-18 level were an independent risk factor for poor prognosis in AIS patients,and high CTRP3 level was an independent protective factor (P＜0.05).The ROC curve showed that the AUC of CCCK-18 combined CTRP3 predicting poor prognosis of AIS patients was significantly greater than that of CCCK-18,CTRP3 alone predicted(P＜0.05),the sensitivity and specificity were 86.36% and 81.44%.Conclusion The serum CCCK-18 level in AIS patients is up-regulated,and the CTRP3 level is down-regulated,which is related to the severity of the disease and poor prognosis.Combined detection of the two can improve the predictive value of poor prognosis.
- Full text:2024072919304596073CCCK-18 and CTRP3 changes in serum of patients with acute ischemic stroke and their clinical significance.pdf
