Clinical analysis of 8 HIV infected patients with Guillain-Barré syndrome
- VernacularTitle:HIV感染合并吉兰-巴雷综合征8例临床分析
- Author:
Ran MIAO
1
;
Wurong LI
1
;
Hongyuan LIANG
1
Author Information
- Publication Type:Journal Article
- Keywords: HIV Infection ； Guillain-Barré syndrome
- From: Journal of Apoplexy and Nervous Diseases 2021;38(9):819-824
- CountryChina
- Language:Chinese
- Abstract: Objective To discuss the clinical characteristics of GBS in HIV-infected patients.Methods In this study we reviewed the clinical data of HIV-infected patients with a diagnosis of GBS attending to Beijing Ditan Hospital from January 2013 to December 2020，and reviewed the literature on this topic.Results We identified eight patients，all are male，aged 28 to 49 years. One patient occurs early in HIV infection，two patient occurs in chronic phase of HIV infection，two patient occurs in AIDS. GBS was the first symptom of HIV infection in three patient. All patients had limbs weakness，seven patients had paresthesias or sensory loss，cranial nerve abnormalities were observed in three patients，one patient has mechanical ventilation. CSF results were available in nine patients，CSF white blood cell was 11～16 cells/μl in six patients，3～5 cells/μl in two patients. CSF protein was increased in six patients and normal in two patients. Recent mycoplasma pneumoniae infection was found in patients 3，5，and 6，recent herpes simplex virus infection in patients 2，and EB virus was found in patients 4 cerebrospinal fluid. Four patients received 5 days of IVIG treatment，one patient was treated with IVIg and steroids，one patient received IVIG and plasmapheresis. Patients 5 had recurrent weakness from 10 weeks after the onset of symptoms. Four patients had improved during the course of treatment，three patients had full recovery. Conclusion HIV GBS occurs in early and late stages of HIV infection，and may follow the onset of AIDS，Clinical signs of GBS are similar for patients regardless of their HIV status，most patients have a good recovery when they received IVIG or plasmapheresis. This case highlighted the need for all clinicians to be aware that patients with symptoms of GBS，regardless of clinical history should be offered an HIV test.
- Full text:2024072910495091965Clinical analysis of 8 HIV infected patients with GuillainBarré syndrome.pdf
