A study of clinical characteristic and rehabilitation outcome in an eight case series with anti-myelin oligodendrocyte glycoprotein IgG associated disorders
- VernacularTitle: 抗髓鞘少突胶质细胞糖蛋白G抗体相关疾病8例临床特点及康复结局研究
- Author:
Haibing XIAO
1
;
Qingyan YANG
1
;
Huiting LIN
1
Author Information
- Publication Type:Journal Article
- Keywords: Anti myelin oligodendrocyte glycoprotein IgG ； MOG-IgG associated disorders； Multiple sclerosis ； Neuromyelitis optica spectrum diseases
- From: Journal of Apoplexy and Nervous Diseases 2021;38(9):813-818
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the clinical features and prognosis of antimyelin oligodendrocyte glycoprotein-IgG （MOG-IgG） associated disorders （MOGAD）.Methods Eight cases met the diagnostic criteria of MOGAD were reviewed，and the demographics，clinical manifestations，laboratory and imaging results，treatment and prognosis were analyzed. The Expanded Disability Status Scale （EDSS） and the modified Rankin Scale （mRS） were used to dynamically evaluate the neurological disability. Results The ratio of male to female in this 8-case series was 1∶1，the median onset age was 34 years old，and the median disease duration was 42 months. The most common initial symptom is optic neuritis （ON，50%），followed by meningitis and/or encephalitis （25%）. Recurrence occurs in 50% of cases，and the recurrence rate of patients with high serum MOG IgG titer （≥1∶32） is 60%. The white blood cells in the cerebrospinal fluid in cases with meningitis/encephalitis or longitudinally extensive myelitis is often>100×10-6/L，which is higher than other phenotypes. There are 6 cases （75%） of patients with different MRI abnormalities，including hypertensity on T-2/Flair image with enhancement at affected optic nerve and orbital tissue，asymptomatic diencephalon/thalamus lesions on T2 and contrasted image，and MRI findings mimic typical multiple sclerosis may also be present. Cases with myelitis can show short-segment eccentric lesions or long-segment central lesions on MRI. Cases with meningitis/encephalitis showed unilateral cortical high T-2/Flair lesions on cranial MRI with various enhancements. After medication and rehabilitation，the peak EDSS of this case series was 5±1.069，and 2.19±1.689 points at the last visit；mRS was 3.25±1.165 points at the peak and 1.25±1.035 points at the last visit. The difference was statistically significant.Conclusions MOGAD is a rare type of demyelinating disease in central nervous with various manifestations，which is highly treatable. Fully understanding of the clinical characteristics，making a early diagnosis through comprehensive tests，and initiating immunization and rehabilitation treatment in time，will contribute to better prognosis for patients.
- Full text:2024072910434091869A study of clinical characteristic and rehabilitation outcome in an eight case series with antimyelin oligodendrocyte glycoprotein IgG associated disorders.pdf
