Ultrastructural changes related to brain vascular and cells damage in alcoholism rats
10.19845/j.cnki.zfysjjbzz.2021.0244
- VernacularTitle:酒精中毒大鼠脑血管及细胞损伤相关超微结构改变
- Author:
Li ZHAO
1
;
Jikui GUAN
1
;
Jiafeng CHEN
1
Author Information
1. The First People Hospital of Wuhu,Wuhu 241000,China
- Publication Type:Journal Article
- Keywords:
Alcoholism ； Cerebrovascular and cellular damage ； Ultramicrostructure
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(10):1110-1112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ultrastructural changes of brain vessels and cells after alcoholism in rats and the underlying mechanisms.Methods Wistar male rats were given alcohol intragastrically for 4 weeks to induce chronic alcoholism model.To observe the ultrastructural changes related to brain vascular and cells damage after alcohol intoxication in rats by a transmission electron microscope.Results The shape of cerebellar capillary endothelial cells was irregular in the alcohol intoxication group，there were fewer organelles in the cytoplasm.The nuclei are irregularly shaped,the nuclei are not obvious,irregular shape.The mitochondria in the frontal lobes are swollen,crest fracture,reduced number,the ribosomes attached to the crest fall off.The tubular rough endoplasmic reticulum is fractured,the interval between each other is widened,the quantity is reduced,the ribosomes attached to the outer surface of the tube membrane fall off.Mild demyelinating changes were observed in the hippocampus,and the lamellar myelin sheath composed of multiple plasma membranes was slightly detached and damaged.Conclusion Alcoholism can cause the change and damage of the ultrastructure of cerebrovascular and related cells.To provide basic research theories and ideas for subsequent prevention and treatment.
- Full text:20240729094152461571Ultrastructural changes related to brain vascular and cells damage in alcoholism rats.pdf
