The value of total cerebral small vessel disease score in intravenous thrombolysis in patients with acute ischemic stroke
10.19845/j.cnki.zfysjjbzz.2021.0241
- VernacularTitle:CSVD总负荷评分在急性缺血性卒中患者静脉溶栓中的应用价值
- Author:
Ziliang ZHUO
1
;
Ying ZHUO
1
;
Zhiyu NIE
1
Author Information
1. The Fifth Clinical Medical College of Yangzhou University Department of Neurology,Changshu Second People Hospital,Changshu 215500,China
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Total cerebral small vessel disease score;
Intravenous thrombolysis;
Outcome prediction;
The optimal population
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(10):1098-1101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of the overall burden of cerebral small vessel disease (CSVD) in AIS patients treated with intravenous thrombolysis and find the optimal population.Methods We retrospectively included 188 AIS patients who received intravenous thrombolysis with rt-PA in the Department of Neurology,Changshu Second People’s Hospital from March 2016 to January 2020.The total CSVD load was assessed based on 3.0 MRI.Multivariate logistic regression was used to analyze the influencing factors associated with 90 d poor prognosis (mRS score≥3).The predictive value of the score in different groups of patients were compared by ROC curve.Results Multivariate analysis showed:diabetes (OR=2.828,95%CI 1.009 to 7.924,P=0.048),smoking (OR=9.396,95%CI 2.690 to 32.823,P<0.001),atrial fibrillation (OR=8.160,95%CI 2.167 to 30.729,P=0.002),baseline NIHSS score (for each additional point:OR=1.379,95%CI 1.241 to 1.5320,P<0.001),total CSVD score ≥3 points (OR=5.448,95%CI 1.720 to 17.260,P=0.004) were independent risk factors for poor prognosis in AIS patients treated with intravenous thrombolysis.ROC curve analysis shows that when 8≤NIHSS≤15,the CSVD total load score has a better predictive effect (C=0.828).Conclusion The total CSVD score≥3 points is an independent risk factor for the poor prognosis of patients with intravenous thrombolysis at 90 days.And the score had the highest predictive value for patients with moderate to severe stroke.
- Full text:2024072909285362870The value of total cerebral small vessel disease score in intravenous thrombolysis in patients with acute ischemic stroke.pdf
