Association between serum homocysteine,white matter hyperintensity and cerebral microbleeds
10.19845/j.cnki.zfysjjbzz.2021.0236
- VernacularTitle:血清同型半胱氨酸、脑白质高信号与颅内微出血相关性研究
- Author:
Lei WANG
1
;
Hongbo PANG
1
;
Zongsheng CHEN
1
Author Information
1. Department of Neurology,Wuhu No.2 People Hospital,Wuhu 241000,China
- Publication Type:Journal Article
- Keywords:
Cerebral microbleeds;
Homocysteine;
White matter hyperintensity
- From:
Journal of Apoplexy and Nervous Diseases
2021;38(10):1079-1082
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association between serum homocysteine (Hcy),white matter hyperintensity (WMH) and cerebral microbleeds (CMBs).Methods 309 patients were divided into CMBs group (n=116) and control group (n=193),lobar CMBs group (n=90) and deep CMBs group (n=26),minor CMBs group (n=78) and major CMBs group (n=38),low-level Hcy group (n=158) and high level Hcy group (n=151) according to the quantity and site of CMBs and the median levels of Hcy.Results The levels of Hcy,glucose,creatinine,the total score of Fazekas scale,systolic pressure and pulse pressure difference were higher in CMBs group than control group (P<0.05);Male,systolic pressure and the total score of Fazekas scale were independent risk factors of CMBs by Logical regression (P<0.05).The scores of Fazekas scale were higher in lobar CMBs group than deep CMBs group (P<0.05);Serum Hcy,the scores of Fazekas scale were related to quantity of CMBs (P<0.05).Conclusions The serum Hcy was partcipated in the process of CMBS.The severity of WMH was correlation with lobar CMBs may play a prediction role in CMBs.
- Full text:202407290911313503Association between serum homocysteine,white matter hyperintensity and cerebral microbleeds.pdf
